Anti-CDK4 Polyclonal Antibody (HY215014)

Name: Anti-CDK4 Polyclonal Antibody
Brand: abinScience
SKU: HY215014
Price: 168 USD
Availability: InStock

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Каталожный номер

HY215014

Описание

Anti-CDK4 Polyclonal Antibody (HY215014) is a rabbit polyclonal antibody detecting CDK4 in ELISA, IHC, WB. Suitable for Human, Mouse, Rat, Bovine, and Ovis aries.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

Реактивность видов

Human, Mouse, Rat

Применения

ELISA, IHC, WB

Хозяинский вид

Rabbit

Клоональность

Polyclonal

Изотип

IgG

Иммуноген

E. coli - derived recombinant Human CDK4 (Met1-Glu303).

Цель

Cell division protein kinase 4, PSK-J3, Cyclin-dependent kinase 4, CDK4

Очистка

Purified by antigen affinity column.

Номер доступа

P11802

Форма

Liquid

Буфер хранения

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии.

Информация об использовании продукта

Применение	Разбавление
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Устойчивость и хранение

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Фон

Cyclin-dependent kinase 4 (CDK4) is a ~33 kDa protein. Ser/Thr-kinase component of cyclin D-CDK4 (DC) complexes that phosphorylate and inhibit members of the retinoblastoma (RB) protein family including RB1 and regulate the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complexes and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also phosphorylates SMAD3 in a cell-cycle-dependent manner and represses its transcriptional activity.

Ссылки

Circular RNA CLASP1 modulates the GLI1/SNAIL axis and enhances macrophage polarization in breast cancer.[HY215014]

Примечание

For research use only.

Изображения

Western blot

Western blot analysis of CCND1 and CDK4 protein levels in MDA-MB-231 and MCF-7 cells transfected with sh-circCLASP1 or sh-scramble.

Ссылки

Circular RNA CLASP1 modulates the GLI1/SNAIL axis and enhances macrophage polarization in breast cancer

Даташит

Anti-CDK4 Polyclonal Antibody.pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Рекомбинантные Белки

Антитела

Наборы для анализа

Anti-CDK4 Polyclonal Antibody (HY215014)

Обзор

Изображения

Ссылки

Даташит

SDS

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