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| カタログ番号 | HA660014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-CDK7 Polyclonal Antibody (HA660014) is a rabbit polyclonal antibody detecting Cyclin-dependent kinase 7; 2.7.11.22; 2.7.11.23; 39 kDa protein kinase; p39 Mo15; CDK-activating kinase 1; Cell division protein kinase 7; Serine/threonine-protein kinase 1; TFIIH basal transcription factor complex kinase subunit; CDK7; CAK; CAK1; CDKN7; MO15; STK1 in ELISA, IHC, WB. Suitable for Human, Rat, Mouse, and Frog.
Highlights
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| 種反応性 | Human, Mouse, Rat | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant human CDK7 (Met1-Phe346). | ||||||||
| ターゲット | Cyclin-dependent kinase 7; 2.7.11.22; 2.7.11.23; 39 kDa protein kinase; p39 Mo15; CDK-activating kinase 1; Cell division protein kinase 7; Serine/threonine-protein kinase 1; TFIIH basal transcription factor complex kinase subunit; CDK7; CAK; CAK1; CDKN7; MO15; STK1 | ||||||||
| エンドトキシンレベル | Please contact with the lab for this information. | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | P50613, P51952, Q03147, P20911 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Cyclin-dependent kinase 7 (CDK7) is a ~39 kDa protein. Serine/threonine kinase involved in cell cycle control and in RNA polymerase II-mediated RNA transcription. Cyclin-dependent kinases (CDKs) are activated by the binding to a cyclin and mediate the progression through the cell cycle. Each different complex controls a specific transition between 2 subsequent phases in the cell cycle. Required for both activation and complex formation of CDK1/cyclin-B during G2-M transition, and for activation of CDK2/cyclins during G1-S transition (but not complex formation). CDK7 is the catalytic subunit of the CDK-activating kinase (CAK) complex. 1. Kershnar, E. et al. (1998) The Journal of biological chemistry 273, 34444-53. PMID: 9852112 2. Lolli, G. (2009) Nucleic acids research 37, 1260-8. PMID: 19136461 3. Nilson, KA. et al. (2015) Molecular cell 59, 576-87. PMID: 26257281 4. Ebmeier, CC. et al. (2017) Cell reports 20, 1173-1186. PMID: 28768201 5. Ko, LJ. et al. (1997) Molecular and cellular biology 17, 7220-9. PMID: 9372954 6. Schneider, E. et al. (1998) Oncogene 17, 2733-41. PMID: 9840937 | ||||||||
| 注意事項 | For research use only |
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