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Anti-CFI Polyclonal Antibody (HY223014)

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Aperçu
Numéro de catalogueHY223014
Description
Anti-CFI Polyclonal Antibody (HY223014) is a rabbit polyclonal antibody detecting CFI in ELISA, IHC, WB. Suitable for Human and Pongo abelii.
Highlights
  • ●Affinity Purified — Minimal background and high purity for reliable results.
  • ●Multi-Application — Validated across multiple applications.
Reactivité des espècesHuman
ApplicationsELISA, IHC, WB
Espèce hôteRabbit
ClonalitéPolyclonal
IsotypeIgG
Immunogène E. coli - derived recombinant Human CFI (Lys19-Ile335).
Cible Complement factor I, CFI, C3B/C4B inactivator, IF
Purification Purified by antigen affinity column.
Numéro d'accès P05156
Forme Liquid
Tampon de stockage 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.
Informations d'utilisation du produit
Application Dilution
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Stabilité et stockage Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Contexte

Complement factor I (CFI) is a ~65 kDa protein. Trypsin-like serine protease that plays an essential role in regulating the immune response by controlling all complement pathways. Inhibits these pathways by cleaving three peptide bonds in the alpha-chain of C3b and two bonds in the alpha-chain of C4b thereby inactivating these proteins. Essential cofactors for these reactions include factor H and C4BP in the fluid phase and membrane cofactor protein/CD46 and CR1 on cell surfaces. The presence of these cofactors on healthy cells allows degradation of deposited C3b by CFI in order to prevent undesired complement activation, while in apoptotic cells or microbes, the absence of such cofactors leads to C3b-mediated complement activation and subsequent opsonization.

1. Timár, KK. et al. (2007) Molecular immunology 44, 2943-9. PMID: 17320177
2. Harrison, RA. et al. (1980) Molecular immunology 17, 9-20. PMID: 7360115
3. Barilla-LaBarca, ML. et al. (2002) Journal of immunology (Baltimore, Md. : 1950) 168, 6298-304. PMID: 12055245
4. Seya, T. et al. (1990) Journal of biochemistry 107, 310-5. PMID: 2141838
5. Sahu, A. et al. (1998) Journal of immunology (Baltimore, Md. : 1950) 160, 5596-604. PMID: 9605165
6. Xue, X. et al. (2017) Nature structural & molecular biology 24, 643-651. PMID: 28671664
Note For research use only.
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Formula
Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)
Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.
Mass
=
Concentration
×
Volume
Molecular Weight *
g/mol
Formula
C₁ × V₁ = C₂ × V₂
Enter any 3 of the 4 values to solve for the unknown.
Stock Solution
C₁ (Stock Conc.)
×
V₁ (Stock Vol.)
=
Working Solution
C₂ (Working Conc.)
×
V₂ (Working Vol.)
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Anti-CFI Polyclonal Antibody

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