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| カタログ番号 | HY223014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-CFI Polyclonal Antibody (HY223014) is a rabbit polyclonal antibody detecting CFI in ELISA, IHC, WB. Suitable for Human and Pongo abelii.
Highlights
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| 種反応性 | Human | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human CFI (Lys19-Ile335). | ||||||||
| ターゲット | Complement factor I, CFI, C3B/C4B inactivator, IF | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | P05156 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Complement factor I (CFI) is a ~65 kDa protein. Trypsin-like serine protease that plays an essential role in regulating the immune response by controlling all complement pathways. Inhibits these pathways by cleaving three peptide bonds in the alpha-chain of C3b and two bonds in the alpha-chain of C4b thereby inactivating these proteins. Essential cofactors for these reactions include factor H and C4BP in the fluid phase and membrane cofactor protein/CD46 and CR1 on cell surfaces. The presence of these cofactors on healthy cells allows degradation of deposited C3b by CFI in order to prevent undesired complement activation, while in apoptotic cells or microbes, the absence of such cofactors leads to C3b-mediated complement activation and subsequent opsonization. 1. Timár, KK. et al. (2007) Molecular immunology 44, 2943-9. PMID: 17320177 2. Harrison, RA. et al. (1980) Molecular immunology 17, 9-20. PMID: 7360115 3. Barilla-LaBarca, ML. et al. (2002) Journal of immunology (Baltimore, Md. : 1950) 168, 6298-304. PMID: 12055245 4. Seya, T. et al. (1990) Journal of biochemistry 107, 310-5. PMID: 2141838 5. Sahu, A. et al. (1998) Journal of immunology (Baltimore, Md. : 1950) 160, 5596-604. PMID: 9605165 6. Xue, X. et al. (2017) Nature structural & molecular biology 24, 643-651. PMID: 28671664 | ||||||||
| 注意事項 | For research use only. |
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