中文
English
한국어
日本語
Español
Français
Русский
| カタログ番号 | ZB997014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-Chicken IL10 Polyclonal Antibody (ZB997014) is a rabbit polyclonal antibody detecting IL10 in ELISA, IHC, WB.
Highlights
|
||||||||
| 種反応性 | Chicken | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Chicken IL10 (Leu22-Arg174). | ||||||||
| テスト済みアプリケーション | WB | ||||||||
| ターゲット | CSIF, Cytokine synthesis inhibitory factor, IL-10, IL10, Interleukin-10 | ||||||||
| エンドトキシンレベル | Please contact with the lab for this information. | ||||||||
| 純度 | >90% as determined by SDS-PAGE. | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | Q6A2H4 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
||||||||
| 製品使用情報 |
| ||||||||
| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 別名 | Q6A2H4 | ||||||||
| 背景 | Interleukin-10 (IL10) is a ~20 kDa protein. Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines including granulocyte-macrophage colony-stimulating factor /GM-CSF, granulocyte colony-stimulating factor/G-CSF, IL-1 alpha, IL-1 beta, IL-6, IL-8 and TNF. Also interferes with antigen presentation by reducing the expression of MHC-class II and co-stimulatory molecules, thereby inhibiting their ability to induce T cell activation. | ||||||||
| 注意事項 | For research use only |
Western blot analysis was performed using anti-IL10 polyclonal antibody at 1ug/mL on various samples.
Lane 1: RAW264.7 cell lysate
Lane 2: THP-1 cell lysate
Lane 3: Mouse spleen lysate
Lane 4: Mouse thymus lysate
+86-027-65523339
中国武漢市深敦寺路666号C棟、武漢、430206
