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| カタログ番号 | HW493014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-CHRNA4 Polyclonal Antibody (HW493014) is a rabbit polyclonal antibody detecting CHRNA4 in ELISA, IHC, WB. Suitable for Human, Mouse, Rat, Chicken, and Pan troglodytes.
Highlights
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| 種反応性 | Human, Mouse, Rat | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human CHRNA4 (Asn49-Leu242). | ||||||||
| ターゲット | Neuronal acetylcholine receptor subunit alpha-4, NACRA4, CHRNA4 | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | P43681 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Neuronal acetylcholine receptor subunit alpha-4 (CHRNA4) is a ~69 kDa protein. Component of neuronal acetylcholine receptors (nAChRs) that function as pentameric, ligand-gated cation channels with high calcium permeability among other activities. nAChRs are excitatory neurotrasnmitter receptors formed by a collection of nAChR subunits known to mediate synaptic transmission in the nervous system and the neuromuscular junction. Each nAchR subunit confers differential attributes to channel properties, including activation, deactivation and desensitization kinetics, pH sensitivity, cation permeability, and binding to allosteric modulators. CHRNA4 forms heteropentameric neuronal acetylcholine receptors with CHRNB2 and CHRNB4, as well as CHRNA5 and CHRNB3 as accesory subunits. Is the most abundant nAChR subtype expressed in the central nervous system. 1. Bondarenko, V. et al. (2012) Biochimica et biophysica acta 1818, 1261-8. PMID: 22361591 2. Morales-Perez, CL. et al. (2016) Nature 538, 411-415. PMID: 27698419 3. Walsh, RM. et al. (2018) Nature 557, 261-265. PMID: 29720657 4. Mazzaferro, S. et al. (2024) British journal of pharmacology 181, 1973-1992. PMID: 38454578 5. Tumkosit, P. et al. (2006) Molecular pharmacology 70, 1358-68. PMID: 16835356 | ||||||||
| 注意事項 | For research use only. |
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