

| Каталожный номер | HW493014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Описание |
Anti-CHRNA4 Polyclonal Antibody (HW493014) is a rabbit polyclonal antibody detecting CHRNA4 in ELISA, IHC, WB. Suitable for Human, Mouse, Rat, Chicken, and Pan troglodytes.
Highlights
|
||||||||
| Реактивность видов | Human, Mouse, Rat | ||||||||
| Применения | ELISA, IHC, WB | ||||||||
| Хозяинский вид | Rabbit | ||||||||
| Клоональность | Polyclonal | ||||||||
| Изотип | IgG | ||||||||
| Иммуноген | E. coli - derived recombinant Human CHRNA4 (Asn49-Leu242). | ||||||||
| Цель | Neuronal acetylcholine receptor subunit alpha-4, NACRA4, CHRNA4 | ||||||||
| Очистка | Purified by antigen affinity column. | ||||||||
| Номер доступа | P43681 | ||||||||
| Форма | Liquid | ||||||||
| Буфер хранения | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии. |
||||||||
| Информация об использовании продукта |
| ||||||||
| Устойчивость и хранение | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| Фон | Neuronal acetylcholine receptor subunit alpha-4 (CHRNA4) is a ~69 kDa protein. Component of neuronal acetylcholine receptors (nAChRs) that function as pentameric, ligand-gated cation channels with high calcium permeability among other activities. nAChRs are excitatory neurotrasnmitter receptors formed by a collection of nAChR subunits known to mediate synaptic transmission in the nervous system and the neuromuscular junction. Each nAchR subunit confers differential attributes to channel properties, including activation, deactivation and desensitization kinetics, pH sensitivity, cation permeability, and binding to allosteric modulators. CHRNA4 forms heteropentameric neuronal acetylcholine receptors with CHRNB2 and CHRNB4, as well as CHRNA5 and CHRNB3 as accesory subunits. Is the most abundant nAChR subtype expressed in the central nervous system. 1. Bondarenko, V. et al. (2012) Biochimica et biophysica acta 1818, 1261-8. PMID: 22361591 2. Morales-Perez, CL. et al. (2016) Nature 538, 411-415. PMID: 27698419 3. Walsh, RM. et al. (2018) Nature 557, 261-265. PMID: 29720657 4. Mazzaferro, S. et al. (2024) British journal of pharmacology 181, 1973-1992. PMID: 38454578 5. Tumkosit, P. et al. (2006) Molecular pharmacology 70, 1358-68. PMID: 16835356 | ||||||||
| Примечание | For research use only. |
Свяжитесь с нами для индивидуальных предложений, оптовых запросов и других вопросов.
Почта: [email protected]
Быстрый доступ
Свяжитесь с нами
+86-027-65523339
Building C, No. 666, Shen Dun Si Lu, Wuhan, 430206, China
中文
English
한국어
日本語
Español
Français
Русский