

| Каталожный номер | HC539014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Описание |
Anti-CHRNB3 Polyclonal Antibody (HC539014) is a rabbit polyclonal antibody detecting CHRNB3 in ELISA, IHC, WB. Suitable for Human.
Highlights
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| Реактивность видов | Human | ||||||||
| Применения | ELISA, IHC, WB | ||||||||
| Хозяинский вид | Rabbit | ||||||||
| Клоональность | Polyclonal | ||||||||
| Изотип | IgG | ||||||||
| Иммуноген | E. coli - derived recombinant Human CHRNB3 (Glu119-Arg230). | ||||||||
| Цель | Neuronal acetylcholine receptor subunit beta-3, CHRNB3 | ||||||||
| Очистка | Purified by antigen affinity column. | ||||||||
| Номер доступа | Q05901 | ||||||||
| Форма | Liquid | ||||||||
| Буфер хранения | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии. |
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| Информация об использовании продукта |
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| Устойчивость и хранение | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| Фон | Neuronal acetylcholine receptor subunit beta-3 (CHRNB3) is a ~52 kDa protein. Component of neuronal acetylcholine receptors (nAChRs) that function as pentameric, ligand-gated cation channels with high calcium permeability among other activities. nAChRs are excitatory neurotrasnmitter receptors formed by a collection of nAChR subunits known to mediate synaptic transmission in the nervous system and the neuromuscular junction. Each nAchR subunit confers differential attributes to channel properties, including activation, deactivation and desensitization kinetics, pH sensitivity, cation permeability, and binding to allosteric modulators. Has an accessory rather than functional role and is only able to form functional nAChRs when co-assembled with another beta subunit. Participates in pentameric assemblies along with CHRNA3, CHRNA4, CHRNA6, CHRNB2 and CHRNB4. 1. Boorman, JP. et al. (2000) The Journal of physiology 529 Pt 3, 565-77. PMID: 11118490 2. Tumkosit, P. et al. (2006) Molecular pharmacology 70, 1358-68. PMID: 16835356 3. Giastas, P. et al. (2022) Molecules (Basel, Switzerland) 27. PMID: 35889515 | ||||||||
| Примечание | For research use only. |
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