

| Каталожный номер | HV992014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Описание |
Anti-CISH Polyclonal Antibody (HV992014) is a rabbit polyclonal antibody detecting CISH in ELISA, IHC, WB. Suitable for Human, Mouse, Rat, and Bovine.
Highlights
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| Реактивность видов | Human, Mouse | ||||||||
| Применения | ELISA, IHC, WB | ||||||||
| Хозяинский вид | Rabbit | ||||||||
| Клоональность | Polyclonal | ||||||||
| Изотип | IgG | ||||||||
| Иммуноген | E. coli - derived recombinant Human CISH (Met1-Leu258). | ||||||||
| Цель | CIS-1, CIS, SOCS, Cytokine-inducible SH2-containing protein, CISH, Protein G18, Suppressor of cytokine signaling, G18 | ||||||||
| Очистка | Purified by antigen affinity column. | ||||||||
| Номер доступа | Q9NSE2 | ||||||||
| Форма | Liquid | ||||||||
| Буфер хранения | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии. |
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| Информация об использовании продукта |
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| Устойчивость и хранение | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| Фон | Cytokine-inducible SH2-containing protein (CISH) is a ~28 kDa protein. SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. CIS is involved in the negative regulation of cytokines that signal through the JAK-STAT5 pathway such as erythropoietin, prolactin and interleukin 3 (IL3) receptor. Inhibits STAT5 trans-activation by suppressing its tyrosine phosphorylation. May be a substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. | ||||||||
| Примечание | For research use only. |
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