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| カタログ番号 | HA683014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-CLCN2 Polyclonal Antibody (HA683014) is a rabbit polyclonal antibody detecting Chloride channel protein 2; ClC-2; CLCN2 in ELISA, IHC, WB. Suitable for Human, Mouse, and Rat.
Highlights
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| 種反応性 | Human | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant human CLCN2 (Leu568-Gly847). | ||||||||
| ターゲット | Chloride channel protein 2; ClC-2; CLCN2 | ||||||||
| エンドトキシンレベル | Please contact with the lab for this information. | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | P51788, Q9R0A1, P35525 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Chloride channel protein 2 (CLCN2) is a ~98 kDa protein. Voltage-gated and osmosensitive chloride channel. Forms a homodimeric channel where each subunit has its own ion conduction pathway. Conducts double-barreled currents controlled by two types of gates, two fast glutamate gates that control each subunit independently and a slow common gate that opens and shuts off both subunits simultaneously. Displays inward rectification currents activated upon membrane hyperpolarization and extracellular hypotonicity. Contributes to chloride conductance involved in neuron excitability. 1. Peña-Münzenmayer, G. et al. (2005) Journal of cell science 118, 4243-52. PMID: 16155254 2. Blanz, J. et al. (2007) The Journal of neuroscience : the official journal of the Society for Neuroscience 27, 6581-9. PMID: 17567819 3. Saint-Martin, C. et al. (2009) Human mutation 30, 397-405. PMID: 19191339 4. Stölting, G. et al. (2013) Pflugers Archiv : European journal of physiology 465, 1423-37. PMID: 23632988 5. Scholl, UI. et al. (2018) Nature genetics 50, 349-354. PMID: 29403011 6. Fernandes-Rosa, FL. et al. (2018) Nature genetics 50, 355-361. PMID: 29403012 7. Xu, P. et al. (2023) Human genetics 142, 577-593. PMID: 36964785 8. Xu, M. et al. (2024) eLife 12. PMID: 38345841 9. Jeworutzki, E. et al. (2012) Neuron 73, 951-61. PMID: 22405205 | ||||||||
| 注意事項 | For research use only |
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