Anti-CLCN2 Polyclonal Antibody (HA683014)

Name: Anti-CLCN2 Polyclonal Antibody
Brand: abinScience
SKU: HA683014
Price: 168 USD
Availability: InStock

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Каталожный номер

HA683014

Описание

Anti-CLCN2 Polyclonal Antibody (HA683014) is a rabbit polyclonal antibody detecting Chloride channel protein 2; ClC-2; CLCN2 in ELISA, IHC, WB. Suitable for Human, Mouse, and Rat.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

Реактивность видов

Human

Применения

ELISA, IHC, WB

Хозяинский вид

Rabbit

Клоональность

Polyclonal

Изотип

IgG

Иммуноген

E. coli - derived recombinant human CLCN2 (Leu568-Gly847).

Цель

Chloride channel protein 2; ClC-2; CLCN2

Уровень эндотоксинов

Please contact with the lab for this information.

Очистка

Purified by antigen affinity column.

Номер доступа

P51788, Q9R0A1, P35525

Форма

Liquid

Буфер хранения

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии.

Информация об использовании продукта

Применение	Разбавление
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Устойчивость и хранение

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Фон

Chloride channel protein 2 (CLCN2) is a ~98 kDa protein. Voltage-gated and osmosensitive chloride channel. Forms a homodimeric channel where each subunit has its own ion conduction pathway. Conducts double-barreled currents controlled by two types of gates, two fast glutamate gates that control each subunit independently and a slow common gate that opens and shuts off both subunits simultaneously. Displays inward rectification currents activated upon membrane hyperpolarization and extracellular hypotonicity. Contributes to chloride conductance involved in neuron excitability.

1. Peña-Münzenmayer, G. et al. (2005) Journal of cell science 118, 4243-52. PMID: 16155254

2. Blanz, J. et al. (2007) The Journal of neuroscience : the official journal of the Society for Neuroscience 27, 6581-9. PMID: 17567819

3. Saint-Martin, C. et al. (2009) Human mutation 30, 397-405. PMID: 19191339

4. Stölting, G. et al. (2013) Pflugers Archiv : European journal of physiology 465, 1423-37. PMID: 23632988

5. Scholl, UI. et al. (2018) Nature genetics 50, 349-354. PMID: 29403011

6. Fernandes-Rosa, FL. et al. (2018) Nature genetics 50, 355-361. PMID: 29403012

7. Xu, P. et al. (2023) Human genetics 142, 577-593. PMID: 36964785

8. Xu, M. et al. (2024) eLife 12. PMID: 38345841

9. Jeworutzki, E. et al. (2012) Neuron 73, 951-61. PMID: 22405205

Примечание

For research use only

Изображения

Ссылки

Даташит

Anti-CLCN2 Polyclonal Antibody.pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Рекомбинантные Белки

Антитела

Наборы для анализа

Anti-CLCN2 Polyclonal Antibody (HA683014)

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