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Anti-CLCN7 Polyclonal Antibody (HW507014)

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Aperçu
Numéro de catalogueHW507014
Description
Anti-CLCN7 Polyclonal Antibody (HW507014) is a rabbit polyclonal antibody detecting CLCN7 in ELISA, IHC, WB. Suitable for Human and Mouse.
Highlights
  • ●Affinity Purified — Minimal background and high purity for reliable results.
  • ●Multi-Application — Validated across multiple applications.
Reactivité des espècesHuman, Mouse, Rat
ApplicationsELISA, IHC, WB
Espèce hôteRabbit
ClonalitéPolyclonal
IsotypeIgG
Immunogène E. coli - derived recombinant Human CLCN7 (Phe597-Thr805).
Cible Chloride channel 7 alpha subunit, CLCN7, ClC-7, Chloride channel protein 7, H(+)/Cl(-) exchange transporter 7
Purification Purified by antigen affinity column.
Numéro d'accès P51798
Forme Liquid
Tampon de stockage 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.
Informations d'utilisation du produit
Application Dilution
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Stabilité et stockage Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Contexte

H(+)/Cl(-) exchange transporter 7 (CLCN7) is a ~88 kDa protein. Slowly voltage-gated channel mediating the exchange of chloride ions against protons. Functions as antiporter and contributes to the acidification of the lysosome lumen and may be involved in maintaining lysosomal pH. The CLC channel family contains both chloride channels and proton-coupled anion transporters that exchange chloride or another anion for protons. The presence of conserved gating glutamate residues is typical for family members that function as antiporters.

1. Graves, AR. et al. (2008) Nature 453, 788-92. PMID: 18449189
2. Leisle, L. et al. (2011) The EMBO journal 30, 2140-52. PMID: 21527911
3. Nicoli, ER. et al. (2019) American journal of human genetics 104, 1127-1138. PMID: 31155284
Note For research use only.
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Fiche technique
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Formula
Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)
Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.
Mass
=
Concentration
×
Volume
Molecular Weight *
g/mol
Formula
C₁ × V₁ = C₂ × V₂
Enter any 3 of the 4 values to solve for the unknown.
Stock Solution
C₁ (Stock Conc.)
×
V₁ (Stock Vol.)
=
Working Solution
C₂ (Working Conc.)
×
V₂ (Working Vol.)
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Anti-CLCN7 Polyclonal Antibody

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