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| カタログ番号 | HW507014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-CLCN7 Polyclonal Antibody (HW507014) is a rabbit polyclonal antibody detecting CLCN7 in ELISA, IHC, WB. Suitable for Human and Mouse.
Highlights
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| 種反応性 | Human, Mouse, Rat | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human CLCN7 (Phe597-Thr805). | ||||||||
| ターゲット | Chloride channel 7 alpha subunit, CLCN7, ClC-7, Chloride channel protein 7, H(+)/Cl(-) exchange transporter 7 | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | P51798 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | H(+)/Cl(-) exchange transporter 7 (CLCN7) is a ~88 kDa protein. Slowly voltage-gated channel mediating the exchange of chloride ions against protons. Functions as antiporter and contributes to the acidification of the lysosome lumen and may be involved in maintaining lysosomal pH. The CLC channel family contains both chloride channels and proton-coupled anion transporters that exchange chloride or another anion for protons. The presence of conserved gating glutamate residues is typical for family members that function as antiporters. 1. Graves, AR. et al. (2008) Nature 453, 788-92. PMID: 18449189 2. Leisle, L. et al. (2011) The EMBO journal 30, 2140-52. PMID: 21527911 3. Nicoli, ER. et al. (2019) American journal of human genetics 104, 1127-1138. PMID: 31155284 | ||||||||
| 注意事項 | For research use only. |
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