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| カタログ番号 | HV788014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-CLEC1B Polyclonal Antibody (HV788014) is a rabbit polyclonal antibody detecting CLEC1B in ELISA, IHC, WB. Suitable for Human.
Highlights
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| 種反応性 | Human | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human CLEC1B (Val56-Pro229). | ||||||||
| ターゲット | CLEC1B, C-type lectin domain family 1 member B, C-type lectin-like receptor 2, CLEC2, CLEC-2 | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | Q9P126 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | C-type lectin domain family 1 member B (CLEC1B) is a ~26 kDa protein. C-type lectin-like receptor that serves as a platelet receptor for the lymphatic endothelial marker PDPN. Plays an essential role in blood/lymphatic vessel separation and thrombus formation through homophilic association. Acts as a negative regulator of lymphatic endothelial cell behavior by inhibiting proliferation, migration, and tube formation. Upon ligand binding, triggers a signaling cascade via sequential activation of SRC and SYK tyrosine kinases, leading to activation of PLCG2. Through this pathway, mediates platelet adhesion, aggregation, and secretion in response to PDPN-expressing cells. 1. Christou, CM. et al. (2008) The Biochemical journal 411, 133-40. PMID: 18215137 2. Osada, M. et al. (2012) The Journal of biological chemistry 287, 22241-52. PMID: 22556408 3. Mori, J. et al. (2008) The Journal of biological chemistry 283, 35419-27. PMID: 18955485 | ||||||||
| 注意事項 | For research use only. |
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