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| カタログ番号 | HB528014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-CNGA3 Polyclonal Antibody (HB528014) is a rabbit polyclonal antibody detecting Cyclic nucleotide-gated cation channel alpha-3; Cone photoreceptor cGMP-gated channel subunit alpha; Cyclic nucleotide-gated channel alpha-3; CNG channel alpha-3; CNG-3; CNG3; CNGA3; CNCG3 in ELISA, IHC, WB. Suitable for Human and Bovine.
Highlights
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| 種反応性 | Human | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant human CNGA3 (Phe503-Gln694). | ||||||||
| ターゲット | Cyclic nucleotide-gated cation channel alpha-3; Cone photoreceptor cGMP-gated channel subunit alpha; Cyclic nucleotide-gated channel alpha-3; CNG channel alpha-3; CNG-3; CNG3; CNGA3; CNCG3 | ||||||||
| エンドトキシンレベル | Please contact with the lab for this information. | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | Q16281, Q29441 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Cyclic nucleotide-gated channel alpha-3 (CNGA3) is a ~78 kDa protein. Pore-forming subunit of the cone cyclic nucleotide-gated channel. Mediates cone photoresponses at bright light converting transient changes in intracellular cGMP levels into electrical signals. In the dark, cGMP levels are high and keep the channel open enabling a steady inward current carried by Na(+) and Ca(2+) ions that leads to membrane depolarization and neurotransmitter release from synaptic terminals. Upon photon absorption cGMP levels decline leading to channel closure and membrane hyperpolarization that ultimately slows neurotransmitter release and signals the presence of light, the end point of the phototransduction cascade. Pore-forming subunit of the gustatory cyclic nucleotide-gated channel. 1. Sundin, OH. et al. (2000) Nature genetics 25, 289-93. PMID: 10888875 2. Peng, C. et al. (2003) The Journal of biological chemistry 278, 34533-40. PMID: 12815043 3. Zheng, X. et al. (2022) Nature structural & molecular biology 29, 40-46. PMID: 34969976 4. Hu, Z. et al. (2023) Nature communications 14, 4284. PMID: 37463923 | ||||||||
| 注意事項 | For research use only |
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