Anti-COPS5 Polyclonal Antibody (HB373014)

Name: Anti-COPS5 Polyclonal Antibody
Brand: abinScience
SKU: HB373014
Price: 96 USD
Availability: InStock

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SDS

Обзор

Каталожный номер

HB373014

Описание

Anti-COPS5 Polyclonal Antibody (HB373014) is a rabbit polyclonal antibody detecting COP9 signalosome complex subunit 5; SGN5; Signalosome subunit 5; 3.4.-.-; Jun activation domain-binding protein 1; COPS5; CSN5; JAB1 in ELISA, IHC, WB. Suitable for Mouse, Human, Frog, and Zebrafish.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

Реактивность видов

Human, Mouse

Применения

ELISA, IHC, WB

Хозяинский вид

Rabbit

Клоональность

Polyclonal

Изотип

IgG

Иммуноген

E. coli - derived recombinant human COPS5 (Met1-Lys230).

Цель

COP9 signalosome complex subunit 5; SGN5; Signalosome subunit 5; 3.4.-.-; Jun activation domain-binding protein 1; COPS5; CSN5; JAB1

Уровень эндотоксинов

Please contact with the lab for this information.

Очистка

Purified by antigen affinity column.

Номер доступа

O35864, Q92905, Q6GLM9, Q6PC30

Форма

Liquid

Буфер хранения

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии.

Информация об использовании продукта

Применение	Разбавление
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Устойчивость и хранение

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Фон

COP9 signalosome complex subunit 5 (COPS5) is a ~37 kDa protein. Probable protease subunit of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of the SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. Promotes the proteasomal degradation of BRSK2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.

Примечание

For research use only

Изображения

Western blot

Western blot analysis was performed using anti-COPS5 polyclonal antibody at 1ug/mL on various samples.
Lane 1: NIH3T3 cell lysate
Lane 2: PC-12 cell lysate

Ссылки

Даташит

Anti-COPS5 Polyclonal Antibody.pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

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