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| カタログ番号 | HB597014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-CORO1C Polyclonal Antibody (HB597014) is a rabbit polyclonal antibody detecting Coronin-1C; Coronin-3; hCRNN4; CORO1C; CRN2; CRNN4 in ELISA, IHC, WB. Suitable for Human, Mouse, and Zebrafish.
Highlights
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| 種反応性 | Human, Mouse | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant human CORO1C (Met1-Arg352). | ||||||||
| ターゲット | Coronin-1C; Coronin-3; hCRNN4; CORO1C; CRN2; CRNN4 | ||||||||
| エンドトキシンレベル | Please contact with the lab for this information. | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | Q9ULV4, Q9WUM4, B0R0D7 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Coronin-1C (CORO1C) is a ~53 kDa protein. Plays a role in directed cell migration by regulating the activation and subcellular location of RAC1. Increases the presence of activated RAC1 at the leading edge of migrating cells. Required for normal organization of the cytoskeleton, including the actin cytoskeleton, microtubules and the vimentin intermediate filaments. Plays a role in endoplasmic reticulum-associated endosome fission: localizes to endosome membrane tubules and promotes recruitment of TMCC1, leading to recruitment of the endoplasmic reticulum to endosome tubules for fission. Endosome membrane fission of early and late endosomes is essential to separate regions destined for lysosomal degradation from carriers to be recycled to the plasma membrane. 1. Williamson, RC. et al. (2014) Journal of cell science 127, 4292-307. PMID: 25074804 2. Williamson, RC. et al. (2015) The Journal of biological chemistry 290, 15437-15449. PMID: 25925950 3. Hoyer, MJ. et al. (2018) Cell 175, 254-265.e14. PMID: 30220460 | ||||||||
| 注意事項 | For research use only |
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