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| カタログ番号 | HW523014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-CPT1A Polyclonal Antibody (HW523014) is a rabbit polyclonal antibody detecting CPT1A in ELISA, IHC, WB. Suitable for Human, Mouse, and Equus caballus.
Highlights
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| 種反応性 | Human | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human CPT1A (Gln406-Thr745). | ||||||||
| ターゲット | CPT1, CPTI-L, Carnitine O-palmitoyltransferase I, liver isoform, CPT1A, CPT I, Carnitine palmitoyltransferase 1A, CPT1-L, Carnitine O-palmitoyltransferase 1, liver isoform | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | P50416 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Carnitine O-palmitoyltransferase 1, liver isoform (CPT1A) is a ~88 kDa protein. Catalyzes the transfer of the acyl group of long-chain fatty acid-CoA conjugates onto carnitine, an essential step for the mitochondrial uptake of long-chain fatty acids and their subsequent beta-oxidation in the mitochondrion. Also possesses a lysine succinyltransferase activity that can regulate enzymatic activity of substrate proteins such as ENO1 and metabolism independent of its classical carnitine O-palmitoyltransferase activity. Plays an important role in hepatic triglyceride metabolism. Also plays a role in inducible regulatory T-cell (iTreg) differentiation once activated by butyryl-CoA that antagonizes malonyl-CoA-mediated CPT1A repression. Sustains the IFN-I response by recruiting ZDHCC4 to palmitoylate MAVS at the mitochondria leading to MAVS stabilization and activation. 1. Prip-Buus, C. et al. (2001) Molecular genetics and metabolism 73, 46-54. PMID: 11350182 2. Gobin, S. et al. (2003) The Journal of biological chemistry 278, 50428-34. PMID: 14517221 3. Wolfgang, MJ. et al. (2006) Proceedings of the National Academy of Sciences of the United States of America 103, 7282-7. PMID: 16651524 4. IJlst, L. et al. (1998) The Journal of clinical investigation 102, 527-31. PMID: 9691089 5. Kurmi, K. et al. (2018) Cell reports 22, 1365-1373. PMID: 29425493 6. Zhang, G. et al. (2023) Molecular cell 83, 4370-4385.e9. PMID: 38016475 | ||||||||
| 注意事項 | For research use only. |
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