Anti-CPT1A Polyclonal Antibody (HW523014)

Name: Anti-CPT1A Polyclonal Antibody
Brand: abinScience
SKU: HW523014
Price: 168 USD
Availability: InStock

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Каталожный номер

HW523014

Описание

Anti-CPT1A Polyclonal Antibody (HW523014) is a rabbit polyclonal antibody detecting CPT1A in ELISA, IHC, WB. Suitable for Human, Mouse, and Equus caballus.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

Реактивность видов

Human

Применения

ELISA, IHC, WB

Хозяинский вид

Rabbit

Клоональность

Polyclonal

Изотип

IgG

Иммуноген

E. coli - derived recombinant Human CPT1A (Gln406-Thr745).

Цель

CPT1, CPTI-L, Carnitine O-palmitoyltransferase I, liver isoform, CPT1A, CPT I, Carnitine palmitoyltransferase 1A, CPT1-L, Carnitine O-palmitoyltransferase 1, liver isoform

Очистка

Purified by antigen affinity column.

Номер доступа

P50416

Форма

Liquid

Буфер хранения

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии.

Информация об использовании продукта

Применение	Разбавление
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Устойчивость и хранение

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Фон

Carnitine O-palmitoyltransferase 1, liver isoform (CPT1A) is a ~88 kDa protein. Catalyzes the transfer of the acyl group of long-chain fatty acid-CoA conjugates onto carnitine, an essential step for the mitochondrial uptake of long-chain fatty acids and their subsequent beta-oxidation in the mitochondrion. Also possesses a lysine succinyltransferase activity that can regulate enzymatic activity of substrate proteins such as ENO1 and metabolism independent of its classical carnitine O-palmitoyltransferase activity. Plays an important role in hepatic triglyceride metabolism. Also plays a role in inducible regulatory T-cell (iTreg) differentiation once activated by butyryl-CoA that antagonizes malonyl-CoA-mediated CPT1A repression. Sustains the IFN-I response by recruiting ZDHCC4 to palmitoylate MAVS at the mitochondria leading to MAVS stabilization and activation.

1. Prip-Buus, C. et al. (2001) Molecular genetics and metabolism 73, 46-54. PMID: 11350182

2. Gobin, S. et al. (2003) The Journal of biological chemistry 278, 50428-34. PMID: 14517221

3. Wolfgang, MJ. et al. (2006) Proceedings of the National Academy of Sciences of the United States of America 103, 7282-7. PMID: 16651524

4. IJlst, L. et al. (1998) The Journal of clinical investigation 102, 527-31. PMID: 9691089

5. Kurmi, K. et al. (2018) Cell reports 22, 1365-1373. PMID: 29425493

6. Zhang, G. et al. (2023) Molecular cell 83, 4370-4385.e9. PMID: 38016475

Примечание

For research use only.

Изображения

Ссылки

Даташит

Anti-CPT1A Polyclonal Antibody.pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

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Anti-CPT1A Polyclonal Antibody (HW523014)

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