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| カタログ番号 | HX957014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-CRADD Polyclonal Antibody (HX957014) is a rabbit polyclonal antibody detecting CRADD in ELISA, IHC, WB. Suitable for Human, Mouse, and Pongo abelii.
Highlights
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| 種反応性 | Human, Mouse | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human CRADD (Met1-Leu140). | ||||||||
| ターゲット | RAIDD, CRADD, RIP-associated protein with a death domain, Caspase and RIP adapter with death domain, Death domain-containing protein CRADD | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | P78560 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Death domain-containing protein CRADD is a ~22 kDa protein. Adapter protein that associates with PIDD1 and the caspase CASP2 to form the PIDDosome, a complex that activates CASP2 and triggers apoptosis. Also recruits CASP2 to the TNFR-1 signaling complex through its interaction with RIPK1 and TRADD and may play a role in the tumor necrosis factor-mediated signaling pathway. 1. Tinel, A. et al. (2004) Science (New York, N.Y.) 304, 843-6. PMID: 15073321 2. Vakifahmetoglu, H. et al. (2006) Oncogene 25, 5683-92. PMID: 16652156 3. Tinel, A. et al. (2007) The EMBO journal 26, 197-208. PMID: 17159900 4. Park, HH. et al. (2007) Cell 128, 533-46. PMID: 17289572 5. Ahmad, M. et al. (1997) Cancer research 57, 615-9. PMID: 9044836 6. Duan, H. et al. (1997) Nature 385, 86-9. PMID: 8985253 | ||||||||
| 注意事項 | For research use only. |
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