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| カタログ番号 | HY284014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-CTSG Polyclonal Antibody (HY284014) is a rabbit polyclonal antibody detecting CTSG in ELISA, IHC, WB. Suitable for Human.
Highlights
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| 種反応性 | Human | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human CTSG (Ile21-Leu255). | ||||||||
| ターゲット | Cathepsin G, CG, CTSG | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | P08311 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Cathepsin G (CTSG) is a ~28 kDa protein. Serine protease with trypsin- and chymotrypsin-like specificity. Also displays antibacterial activity against Gram-negative and Gram-positive bacteria independent of its protease activity. Prefers Phe and Tyr residues in the P1 position of substrates but also cleaves efficiently after Trp and Leu. Shows a preference for negatively charged amino acids in the P2' position and for aliphatic amino acids both upstream and downstream of the cleavage site. Required for recruitment and activation of platelets which is mediated by the F2RL3/PAR4 platelet receptor. 1. Thorpe, M. et al. (2018) PloS one 13, e0195077. PMID: 29652924 2. Avril, LE. et al. (1994) FEBS letters 345, 81-6. PMID: 8194606 3. Bangalore, N. et al. (1990) The Journal of biological chemistry 265, 13584-8. PMID: 2116408 4. Alford, CE. et al. (1990) Journal of general microbiology 136, 997-100. PMID: 2117044 5. Sambrano, GR. et al. (2000) The Journal of biological chemistry 275, 6819-23. PMID: 10702240 6. Selak, MA. et al. (1988) The Biochemical journal 251, 293-9. PMID: 3390156 7. Hase-Yamazaki, T. et al. (1995) Cellular immunology 160, 24-32. PMID: 7842483 8. Yamazaki, T. et al. (1997) Journal of leukocyte biology 61, 73-9. PMID: 9000539 | ||||||||
| 注意事項 | For research use only. |
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