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Anti-CUBN Polyclonal Antibody (HT153014)

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Vista general
Número de catálogoHT153014
Descripción
Anti-CUBN Polyclonal Antibody (HT153014) is a rabbit polyclonal antibody detecting CUBN in ELISA, IHC, WB. Suitable for Human.
Highlights
  • ●Affinity Purified — Minimal background and high purity for reliable results.
  • ●Multi-Application — Validated across multiple applications.
Reactividad de especiesHuman
AplicacionesELISA, IHC, WB
Especie huéspedRabbit
ClonalidadPolyclonal
IsotipoIgG
Inmunógeno E. coli - derived recombinant Human CUBN (Cys3511-Ser3623).
Objetivo Cubilin, 460 kDa receptor, Intrinsic factor-vitamin B12 receptor, IFCR, Intestinal intrinsic factor receptor, Intrinsic factor-cobalamin receptor, CUBN
Nivel de endotoxinas Please contact with the lab for this information.
Purificación Purified by antigen affinity column.
Número de acceso O60494
Forma Liquid
Buffer de almacenamiento 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.
Información de uso del producto
Aplicación Dilución
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Estabilidad y almacenamiento Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Fondo

Cubilin (CUBN) is a ~398 kDa protein. Endocytic receptor which plays a role in lipoprotein, vitamin and iron metabolism by facilitating their uptake. Acts together with LRP2 to mediate endocytosis of high-density lipoproteins, GC, hemoglobin, ALB, TF and SCGB1A1. Acts together with AMN to mediate endocytosis of the CBLIF-cobalamin complex. Binds to ALB, MB, Kappa and lambda-light chains, TF, hemoglobin, GC, SCGB1A1, APOA1, high density lipoprotein, and the CBLIF-cobalamin complex. Ligand binding requires calcium.

1. Kozyraki, R. et al. (1999) Nature medicine 5, 656-61. PMID: 10371504
2. Kozyraki, R. et al. (2001) Proceedings of the National Academy of Sciences of the United States of America 98, 12491-6. PMID: 11606717
3. Nykjaer, A. et al. (2001) Proceedings of the National Academy of Sciences of the United States of America 98, 13895-900. PMID: 11717447
4. Fyfe, JC. et al. (2004) Blood 103, 1573-9. PMID: 14576052
5. Kozyraki, R. et al. (1998) Blood 91, 3593-600. PMID: 9572993
Nota For research use only.
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Datasheet
Download SDS PDF
Formula
Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)
Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.
Mass
=
Concentration
×
Volume
Molecular Weight *
g/mol
Formula
C₁ × V₁ = C₂ × V₂
Enter any 3 of the 4 values to solve for the unknown.
Stock Solution
C₁ (Stock Conc.)
×
V₁ (Stock Vol.)
=
Working Solution
C₂ (Working Conc.)
×
V₂ (Working Vol.)
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Anti-CUBN Polyclonal Antibody

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