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Anti-CUBN Polyclonal Antibody (HT153014)

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Aperçu
Numéro de catalogueHT153014
Description
Anti-CUBN Polyclonal Antibody (HT153014) is a rabbit polyclonal antibody detecting CUBN in ELISA, IHC, WB. Suitable for Human.
Highlights
  • ●Affinity Purified — Minimal background and high purity for reliable results.
  • ●Multi-Application — Validated across multiple applications.
Reactivité des espècesHuman
ApplicationsELISA, IHC, WB
Espèce hôteRabbit
ClonalitéPolyclonal
IsotypeIgG
Immunogène E. coli - derived recombinant Human CUBN (Cys3511-Ser3623).
Cible Cubilin, 460 kDa receptor, Intrinsic factor-vitamin B12 receptor, IFCR, Intestinal intrinsic factor receptor, Intrinsic factor-cobalamin receptor, CUBN
Niveau d'endotoxines Please contact with the lab for this information.
Purification Purified by antigen affinity column.
Numéro d'accès O60494
Forme Liquid
Tampon de stockage 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.
Informations d'utilisation du produit
Application Dilution
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Stabilité et stockage Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Contexte

Cubilin (CUBN) is a ~398 kDa protein. Endocytic receptor which plays a role in lipoprotein, vitamin and iron metabolism by facilitating their uptake. Acts together with LRP2 to mediate endocytosis of high-density lipoproteins, GC, hemoglobin, ALB, TF and SCGB1A1. Acts together with AMN to mediate endocytosis of the CBLIF-cobalamin complex. Binds to ALB, MB, Kappa and lambda-light chains, TF, hemoglobin, GC, SCGB1A1, APOA1, high density lipoprotein, and the CBLIF-cobalamin complex. Ligand binding requires calcium.

1. Kozyraki, R. et al. (1999) Nature medicine 5, 656-61. PMID: 10371504
2. Kozyraki, R. et al. (2001) Proceedings of the National Academy of Sciences of the United States of America 98, 12491-6. PMID: 11606717
3. Nykjaer, A. et al. (2001) Proceedings of the National Academy of Sciences of the United States of America 98, 13895-900. PMID: 11717447
4. Fyfe, JC. et al. (2004) Blood 103, 1573-9. PMID: 14576052
5. Kozyraki, R. et al. (1998) Blood 91, 3593-600. PMID: 9572993
Note For research use only.
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Reférences
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Formula
Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)
Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.
Mass
=
Concentration
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Volume
Molecular Weight *
g/mol
Formula
C₁ × V₁ = C₂ × V₂
Enter any 3 of the 4 values to solve for the unknown.
Stock Solution
C₁ (Stock Conc.)
×
V₁ (Stock Vol.)
=
Working Solution
C₂ (Working Conc.)
×
V₂ (Working Vol.)
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Anti-CUBN Polyclonal Antibody

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