Anti-Human CXCL10/IP-10 Polyclonal Antibody (HY524014)

Name: Anti-Human CXCL10/IP-10 Polyclonal Antibody
Brand: abinScience
SKU: HY524014
Price: 168 USD
Availability: InStock

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50ug
100ug

Número:

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Número de catálogo

HY524014

Descripción

Anti-CXCL10/IP-10 Polyclonal Antibody (HY524014) is a rabbit polyclonal antibody detecting IP-10 in ELISA, IHC, WB. Suitable for Human, Macaca mulatta, and Macaca nemestrina.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

Reactividad de especies

Human

Aplicaciones

ELISA, IHC, WB

Especie huésped

Rabbit

Clonalidad

Polyclonal

Isotipo

IgG

Inmunógeno

E. coli - derived recombinant Human CXCL10/IP-10 (Val22-Pro98).

Objetivo

Gamma-IP10, C-X-C motif chemokine 10, INP10, 10 kDa interferon gamma-induced protein, Small-inducible cytokine B10, SCYB10, IP-10, CXCL10

Purificación

Purified by antigen affinity column.

Número de acceso

P02778

Forma

Liquid

Buffer de almacenamiento

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.

Información de uso del producto

Aplicación	Dilución
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Estabilidad y almacenamiento

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Fondo

C-X-C motif chemokine 10 (CXCL10/IP-10) is a ~10 kDa protein. Pro-inflammatory cytokine that is involved in a wide variety of processes such as chemotaxis, differentiation, and activation of peripheral immune cells, regulation of cell growth, apoptosis and modulation of angiostatic effects. Plays thereby an important role during viral infections by stimulating the activation and migration of immune cells to the infected sites. Mechanistically, binding of CXCL10 to the CXCR3 receptor activates G protein-mediated signaling and results in downstream activation of phospholipase C-dependent pathway, an increase in intracellular calcium production and actin reorganization. In turn, recruitment of activated Th1 lymphocytes occurs at sites of inflammation. Activation of the CXCL10/CXCR3 axis also plays an important role in neurons in response to brain injury for activating microglia, the resident macrophage population of the central nervous system, and directing them to the lesion site.

1. Romagnani, P. et al. (2001) Blood 97, 601-7. PMID: 11157474

2. Sidahmed, AM. et al. (2012) Cytokine 59, 433-41. PMID: 22652417

3. Angiolillo, AL. et al. (1995) The Journal of experimental medicine 182, 155-62. PMID: 7540647

4. Smit, MJ. et al. (2003) Blood 102, 1959-65. PMID: 12750173

5. Gao, JM. et al. (2009) Acta pharmacologica Sinica 30, 193-201. PMID: 19151743

6. Cheeran, MC. et al. (2003) Journal of virology 77, 4502-15. PMID: 12663757

Nota

For research use only.

Imágenes

Referencias

Datasheet

Anti-Human CXCL10/IP-10 Polyclonal Antibody.pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Proteínas Recombinantes

Anticuerpos

Kits de Ensayo

Anti-Human CXCL10/IP-10 Polyclonal Antibody (HY524014)

Vista general

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Referencias

Datasheet

SDS