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| カタログ番号 | HV972014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-CYGB Polyclonal Antibody (HV972014) is a rabbit polyclonal antibody detecting CYGB in ELISA, IHC, WB. Suitable for Human, Mouse, Rat.
Highlights
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| 種反応性 | Human, Mouse, Rat | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human CYGB (Met1-Pro190). | ||||||||
| ターゲット | Histoglobin, CYGB, Stellate cell activation-associated protein, Cytoglobin, STAP, HGb | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | Q8WWM9 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Cytoglobin (CYGB) is a ~21 kDa protein. Probable multifunctional globin with a hexacoordinated heme iron required for the catalysis of various reactions depending on redox condition of the cell as well as oxygen availability. Has a nitric oxide dioxygenase (NOD) activity and is most probably involved in cell-mediated and oxygen-dependent nitric oxide consumption. By scavenging this second messenger may regulate several biological processes including endothelium-mediated vasodilation and vascular tone. Under normoxic conditions functions as a nitric oxide dioxygenase (NOD) but under hypoxic conditions the globin may switch its function to that of a nitrite (NO2) reductase (NiR), generating nitric oxide. Could also have peroxidase and superoxide dismutase activities, detoxifying reactive oxygen species and protecting cells against oxidative stress. 1. Trent, JT. et al. (2002) The Journal of biological chemistry 277, 19538-45. PMID: 11893755 2. Asahina, K. et al. (2002) Biochimica et biophysica acta 1577, 471-5. PMID: 12359339 3. Sugimoto, H. et al. (2004) Journal of molecular biology 339, 873-85. PMID: 15165856 4. Halligan, KE. et al. (2009) The Journal of biological chemistry 284, 8539-47. PMID: 19147491 5. Gardner, AM. et al. (2010) The Journal of biological chemistry 285, 23850-7. PMID: 20511233 6. Liu, X. et al. (2017) Nature communications 8, 14807. PMID: 28393874 7. Amdahl, MB. et al. (2017) Biochemistry 56, 3993-4004. PMID: 28671819 8. Reeder, BJ. et al. (2018) Nitric oxide : biology and chemistry 72, 16-23. PMID: 29128400 9. Dat, NQ. et al. (2021) Hepatology (Baltimore, Md.) 73, 2527-2545. PMID: 33576020 10. Zweier, JL. et al. (2021) Proceedings of the National Academy of Sciences of the United States of America 118. PMID: 34930834 | ||||||||
| 注意事項 | For research use only. |
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