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| カタログ番号 | HB959014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-CYP11B1 Polyclonal Antibody (HB959014) is a rabbit polyclonal antibody detecting CYP11B1 in ELISA, IHC, WB. Suitable for Human.
Highlights
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| 種反応性 | Human | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human CYP11B1 (Gly134-Asn503). | ||||||||
| ターゲット | CYP11B1, Cytochrome P-450c11, Steroid 11-beta-hydroxylase, CYP11B1, Cytochrome P450C11, CYPXIB1, Cytochrome P450 11B1, mitochondrial, S11BH | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | P15538 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Cytochrome P450 11B1, mitochondrial (CYP11B1) is a ~57 kDa protein. A cytochrome P450 monooxygenase involved in the biosynthesis of adrenal corticoids. Catalyzes a variety of reactions that are essential for many species, including detoxification, defense, and the formation of endogenous chemicals like steroid hormones. Steroid 11beta, 18- and 19-hydroxylase with preferred regioselectivity at 11beta, then 18, and lastly 19. Catalyzes the hydroxylation of 11-deoxycortisol and 11-deoxycorticosterone (21-hydroxyprogesterone) at 11beta position, yielding cortisol or corticosterone, respectively, but cannot produce aldosterone. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate for hydroxylation and reducing the second into a water molecule. 1. Bureik, M. et al. (2002) Endocrine research 28, 351-5. PMID: 12530636 2. Pascoe, L. et al. (1992) Proceedings of the National Academy of Sciences of the United States of America 89, 8327-31. PMID: 1518866 3. Curnow, KM. et al. (1991) Molecular endocrinology (Baltimore, Md.) 5, 1513-22. PMID: 1775135 4. Zöllner, A. et al. (2008) The FEBS journal 275, 799-810. PMID: 18215163 5. Strushkevich, N. et al. (2013) Molecular endocrinology (Baltimore, Md.) 27, 315-24. PMID: 23322723 | ||||||||
| 注意事項 | For research use only. |
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