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| カタログ番号 | HY444014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-CYP17A1 Polyclonal Antibody (HY444014) is a rabbit polyclonal antibody detecting CYP17A1 in ELISA, IHC, WB. Suitable for Human, Macaca fascicularis, Macaca mulatta, Pan troglodytes, and Papio cynocephalus.
Highlights
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| 種反応性 | Human | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human CYP17A1 (Cys183-Thr508). | ||||||||
| ターゲット | Steroid 17-alpha-hydroxylase/17, 20 lyase, CYPXVII, Cytochrome P450 17A1, Cytochrome P450-C17, Steroid 17-alpha-monooxygenase, 17-alpha-hydroxyprogesterone aldolase, CYP17A1, S17AH, Cytochrome P450c17, CYP17 | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | P05093 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Steroid 17-alpha-hydroxylase/17,20 lyase (CYP17A1) is a ~57 kDa protein. A cytochrome P450 monooxygenase involved in corticoid and androgen biosynthesis. Catalyzes 17-alpha hydroxylation of C21 steroids, which is common for both pathways. A second oxidative step, required only for androgen synthesis, involves an acyl-carbon cleavage. The 17-alpha hydroxy intermediates, as part of adrenal glucocorticoids biosynthesis pathway, are precursors of cortisol (Probable). Hydroxylates steroid hormones, pregnenolone and progesterone to form 17-alpha hydroxy metabolites, followed by the cleavage of the C17-C20 bond to form C19 steroids, dehydroepiandrosterone (DHEA) and androstenedione. 1. DeVore, NM. et al. (2012) Nature 482, 116-9. PMID: 22266943 2. Petrunak, EM. et al. (2014) The Journal of biological chemistry 289, 32952-64. PMID: 25301938 3. Yoshimoto, FK. et al. (2016) The Journal of biological chemistry 291, 17143-64. PMID: 27339894 4. Auchus, RJ. et al. (1998) The Journal of biological chemistry 273, 3158-65. PMID: 9452426 5. Lee, SG. et al. (2023) Journal of inorganic biochemistry 240, 112085. PMID: 36640554 | ||||||||
| 注意事項 | For research use only. |
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