

| Numéro de catalogue | HT346024 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Description |
Anti-CYP26A1 Polyclonal Antibody (HT346024) is a rabbit polyclonal antibody detecting CYP26A1 in ELISA, IHC, WB. Suitable for Human, Mouse, and Rat.
Highlights
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| Reactivité des espèces | Human, Mouse | ||||||||
| Applications | ELISA, IHC, WB | ||||||||
| Espèce hôte | Rabbit | ||||||||
| Clonalité | Polyclonal | ||||||||
| Isotype | IgG | ||||||||
| Immunogène | E. coli - derived recombinant Human CYP26A1 (Lys361-Ile497). | ||||||||
| Cible | P450RAI1, Cytochrome P450 26A1, Cytochrome P450RAI, hP450RAI, CYP26A1, Cytochrome P450 retinoic acid-inactivating 1, Retinoic acid-metabolizing cytochrome, CYP26, Retinoic acid 4-hydroxylase | ||||||||
| Purification | Purified by antigen affinity column. | ||||||||
| Numéro d'accès | O43174 | ||||||||
| Forme | Liquid | ||||||||
| Tampon de stockage | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot. |
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| Informations d'utilisation du produit |
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| Stabilité et stockage | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| Contexte | Cytochrome P450 26A1 (CYP26A1) is a ~56 kDa protein. A cytochrome P450 monooxygenase involved in the metabolism of retinoates (RAs), the active metabolites of vitamin A, and critical signaling molecules in animals. RAs exist as at least four different isomers: all-trans-RA (atRA), 9-cis-RA, 13-cis-RA, and 9,13-dicis-RA, where atRA is considered to be the biologically active isomer, although 9-cis-RA and 13-cis-RA also have activity (Probable). Catalyzes the hydroxylation of atRA primarily at C-4 and C-18, thereby contributing to the regulation of atRA homeostasis and signaling. Hydroxylation of atRA limits its biological activity and initiates a degradative process leading to its eventual elimination (Probable). Involved in the convertion of atRA to all-trans-4-oxo-RA. 1. Topletz, AR. et al. (2012) Biochemical pharmacology 83, 149-63. PMID: 22020119 2. White, JA. et al. (1997) The Journal of biological chemistry 272, 18538-41. PMID: 9228017 3. Sonneveld, E. et al. (1998) Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 9, 629-37. PMID: 9716180 4. Foti, RS. et al. (2016) The Journal of pharmacology and experimental therapeutics 357, 281-92. PMID: 26937021 | ||||||||
| Note | For research use only. |



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