中文
English
한국어
日本語
Español
Français
Русский
| カタログ番号 | HY264014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-CYP3A4 Polyclonal Antibody (HY264014) is a rabbit polyclonal antibody detecting CYP3A4 in ELISA, IHC, WB. Suitable for Human, Callithrix jacchus, and Macaca fascicularis.
Highlights
|
||||||||
| 種反応性 | Human | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human CYP3A4 (Gly26-Ala503). | ||||||||
| ターゲット | CYPIIIA3, Cytochrome P450 3A4, 1, 4-cineole 2-exo-monooxygenase, CYP3A4, Cytochrome P450 3A3, Cytochrome P450 NF-25, Cytochrome P450-PCN1, CYPIIIA4, 1, 8-cineole 2-exo-monooxygenase, Albendazole monooxygenase (sulfoxide-forming), Nifedipine oxidase, Quinine 3-monooxygenase, CYP3A3, Cholesterol 25-hydroxylase, Cytochrome P450 HLp, Albendazole sulfoxidase | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | P08684 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
||||||||
| 製品使用情報 |
| ||||||||
| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Cytochrome P450 3A4 (CYP3A4) is a ~57 kDa protein. A cytochrome P450 monooxygenase involved in the metabolism of sterols, steroid hormones, retinoids and fatty acids. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy E1 and E2, as well as D-ring hydroxylated E1 and E2 at the C-16 position. Plays a role in the metabolism of androgens, particularly in oxidative deactivation of testosterone. 1. Chen, H. et al. (2000) Drug metabolism and disposition: the biological fate of chemicals 28, 315-22. PMID: 10681376 2. Marill, J. et al. (2000) Molecular pharmacology 58, 1341-8. PMID: 11093772 3. Badawi, AF. et al. (2001) Metabolism: clinical and experimental 50, 1001-3. PMID: 11555828 4. Lee, AJ. et al. (2003) Endocrinology 144, 3382-98. PMID: 12865317 5. Lee, AJ. et al. (2003) Cancer research 63, 6532-6. PMID: 14559847 6. Krauser, JA. et al. (2004) European journal of biochemistry 271, 3962-9. PMID: 15373842 7. Choi, MH. et al. (2005) Drug metabolism and disposition: the biological fate of chemicals 33, 714-8. PMID: 15764715 8. Lucas, D. et al. (2010) Journal of lipid research 51, 1125-33. PMID: 19965576 9. Pratt-Hyatt, M. et al. (2010) Drug metabolism and disposition: the biological fate of chemicals 38, 2075-82. PMID: 20702771 10. Peng, CC. et al. (2011) Clinical pharmacology and therapeutics 89, 888-95. PMID: 21490593 | ||||||||
| 注意事項 | For research use only. |
お問い合わせ
+86-027-65523339
中国武漢市深敦寺路666号C棟、武漢、430206
