中文
English
한국어
日本語
Español
Français
Русский
| カタログ番号 | HB872014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-CYP3A7 Polyclonal Antibody (HB872014) is a rabbit polyclonal antibody detecting CYP3A7 in ELISA, IHC, WB. Suitable for Human, Callithrix jacchus, and Macaca fascicularis.
Highlights
|
||||||||
| 種反応性 | Human | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human CYP3A7 (Pro344-Asp497). | ||||||||
| ターゲット | CYP3A7, CYPIIIA7, P450HLp2, Cytochrome P450 3A7, Cytochrome P450-HFLA | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | P24462 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
||||||||
| 製品使用情報 |
| ||||||||
| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Cytochrome P450 3A7 (CYP3A7) is a ~57 kDa protein. A cytochrome P450 monooxygenase involved in the metabolism of steroid hormones and vitamins during embryogenesis. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Metabolizes 3beta-hydroxyandrost-5-en-17-one (dehydroepiandrosterone, DHEA), a precursor in the biosynthesis of androgen and estrogen steroid hormones. Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1), particularly D-ring hydroxylated estrone at the C16-alpha position. 1. Marill, J. et al. (2000) Molecular pharmacology 58, 1341-8. PMID: 11093772 2. Lee, AJ. et al. (2003) Endocrinology 144, 3382-98. PMID: 12865317 3. Lee, AJ. et al. (2003) Cancer research 63, 6532-6. PMID: 14559847 4. Torimoto, N. et al. (2007) Drug metabolism and disposition: the biological fate of chemicals 35, 484-92. PMID: 17178770 5. Ohmori, S. et al. (1998) Biochimica et biophysica acta 1380, 297-304. PMID: 9555064 | ||||||||
| 注意事項 | For research use only. |
お問い合わせ
+86-027-65523339
中国武漢市深敦寺路666号C棟、武漢、430206
