

| Numéro de catalogue | HX130014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Description |
Anti-DCD Polyclonal Antibody (HX130014) is a rabbit polyclonal antibody detecting DCD in ELISA, IHC, WB. Suitable for Human.
Highlights
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| Reactivité des espèces | Human | ||||||||
| Applications | ELISA, IHC, WB | ||||||||
| Espèce hôte | Rabbit | ||||||||
| Clonalité | Polyclonal | ||||||||
| Isotype | IgG | ||||||||
| Immunogène | E. coli - derived recombinant Human DCD (Cys18-Leu110). | ||||||||
| Cible | DCD, AIDD, DSEP, Dermcidin, Preproteolysin | ||||||||
| Purification | Purified by antigen affinity column. | ||||||||
| Numéro d'accès | P81605 | ||||||||
| Forme | Liquid | ||||||||
| Tampon de stockage | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot. |
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| Informations d'utilisation du produit |
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| Stabilité et stockage | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| Contexte | Dermcidin (DCD) is a ~11 kDa protein. Found in sweat, has an antimicrobial activity during early bacterial colonization. The secreted peptide assembles into homohexameric complexes that can associate with and also insert into pathogen membranes. Once inserted in bacteria membranes forms anion channels probably altering the transmembrane potential essential for bacterial survival. Highly effective against E.coli, E.faecalis, S.aureus and C.albicans. Optimal pH and salt concentration resemble the conditions in sweat. 1. Schittek, B. et al. (2001) Nature immunology 2, 1133-7. PMID: 11694882 2. Song, C. et al. (2013) Proceedings of the National Academy of Sciences of the United States of America 110, 4586-91. PMID: 23426625 3. Lee Motoyama, JP. et al. (2007) Biochemical and biophysical research communications 357, 828-33. PMID: 17448443 | ||||||||
| Note | For research use only. |
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