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| カタログ番号 | HV031014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-DDB2 Polyclonal Antibody (HV031014) is a rabbit polyclonal antibody detecting DDB2 in ELISA, IHC, WB. Suitable for Human, Mouse, and Bovine.
Highlights
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| 種反応性 | Human | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human DDB2 (Pro166-Met383). | ||||||||
| ターゲット | Damage-specific DNA-binding protein 2, DNA damage-binding protein 2, UV-damaged DNA-binding protein 2, DDB2, UV-DDB 2, DDBb, DDB p48 subunit | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | Q92466 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | DNA damage-binding protein 2 (DDB2) is a ~47 kDa protein. Protein, which is both involved in DNA repair and protein ubiquitination, as part of the UV-DDB complex and DCX (DDB1-CUL4-X-box) complexes, respectively. Core component of the UV-DDB complex (UV-damaged DNA-binding protein complex), a complex that recognizes UV-induced DNA damage and recruit proteins of the nucleotide excision repair pathway (the NER pathway) to initiate DNA repair. The UV-DDB complex preferentially binds to cyclobutane pyrimidine dimers (CPD), 6-4 photoproducts (6-4 PP), apurinic sites and short mismatches. Also functions as the substrate recognition module for the DCX (DDB2-CUL4-X-box) E3 ubiquitin-protein ligase complex DDB2-CUL4-ROC1 (also known as CUL4-DDB-ROC1 and CUL4-DDB-RBX1). The DDB2-CUL4-ROC1 complex may ubiquitinate histone H2A, histone H3 and histone H4 at sites of UV-induced DNA damage. 1. Tang, JY. et al. (2000) Molecular cell 5, 737-44. PMID: 10882109 2. Wakasugi, M. et al. (2001) The Journal of biological chemistry 276, 15434-40. PMID: 11278856 3. Wakasugi, M. et al. (2002) The Journal of biological chemistry 277, 1637-40. PMID: 11705987 4. Groisman, R. et al. (2003) Cell 113, 357-67. PMID: 12732143 5. Sugasawa, K. et al. (2005) Cell 121, 387-400. PMID: 15882621 6. Kapetanaki, MG. et al. (2006) Proceedings of the National Academy of Sciences of the United States of America 103, 2588-93. PMID: 16473935 7. Guerrero-Santoro, J. et al. (2008) Cancer research 68, 5014-22. PMID: 18593899 8. Geng, A. et al. (2020) Nucleic acids research 48, 9181-9194. PMID: 32789493 9. Hwang, BJ. et al. (1999) Proceedings of the National Academy of Sciences of the United States of America 96, 424-8. PMID: 9892649 | ||||||||
| 注意事項 | For research use only. |
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