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| カタログ番号 | HA609014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-DDX6 Polyclonal Antibody (HA609014) is a rabbit polyclonal antibody detecting Probable ATP-dependent RNA helicase DDX6; 3.6.4.13; ATP-dependent RNA helicase p54; DEAD box protein 6; Oncogene RCK; DDX6; HLR2; RCK in ELISA, IHC, WB. Suitable for Human, Chicken, Mouse, and Frog.
Highlights
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| 種反応性 | Human, Mouse | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant human DDX6 (Glu97-Pro483). | ||||||||
| ターゲット | Probable ATP-dependent RNA helicase DDX6; 3.6.4.13; ATP-dependent RNA helicase p54; DEAD box protein 6; Oncogene RCK; DDX6; HLR2; RCK | ||||||||
| エンドトキシンレベル | Please contact with the lab for this information. | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | P26196, Q5ZKB9, P54823, P54824 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Probable ATP-dependent RNA helicase DDX6 is a ~54 kDa protein. Essential for the formation of P-bodies, cytosolic membrane-less ribonucleoprotein granules involved in RNA metabolism through the coordinated storage of mRNAs encoding regulatory functions. Plays a role in P-bodies to coordinate the storage of translationally inactive mRNAs in the cytoplasm and prevent their degradation. In the process of mRNA degradation, plays a role in mRNA decapping. Blocks autophagy in nutrient-rich conditions by repressing the expression of ATG-related genes through degradation of their transcripts. 1. Ayache, J. et al. (2015) Molecular biology of the cell 26, 2579-95. PMID: 25995375 2. Kamenska, A. et al. (2016) Nucleic acids research 44, 6318-34. PMID: 27342281 3. Balak, C. et al. (2019) American journal of human genetics 105, 509-525. PMID: 31422817 4. Fenger-Grøn, M. et al. (2005) Molecular cell 20, 905-15. PMID: 16364915 5. Hu, G. et al. (2015) Nature cell biology 17, 930-942. PMID: 26098573 | ||||||||
| 注意事項 | For research use only |
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