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| カタログ番号 | HX987014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-DEFA3 Polyclonal Antibody (HX987014) is a rabbit polyclonal antibody detecting DEFA3 in ELISA, IHC, WB. Suitable for Human, Macaca mulatta, Pan troglodytes, and Papio hamadryas.
Highlights
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| 種反応性 | Human | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human DEFA3 (Pro21-Cys94). | ||||||||
| ターゲット | HP3, Neutrophil defensin 3, HNP-3, HNP-2, DEF3, HP-3, Defensin, alpha 3, DEFA3, HP-2, HP2 | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | P59666 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Neutrophil defensin 3 (DEFA3) is a ~10 kDa protein. Effector molecule of the innate immune system that acts via antibiotic-like properties against a broad array of infectious agents including bacteria, fungi, and viruses. Possesses the ability to neutralize bacterial toxins such as B.anthracis lethal factor, Clostridium difficile cytotoxin B as well as leukocidin produced by Staphylococcus aureus. Also blocks herpes simplex virus infection by interacting with envelope glycoprotein B and thus preventing its binding to heparan sulfate, the receptor for attachment. 1. Ericksen, B. et al. (2005) Antimicrobial agents and chemotherapy 49, 269-75. PMID: 15616305 2. Kim, C. et al. (2005) Proceedings of the National Academy of Sciences of the United States of America 102, 4830-5. PMID: 15772169 3. Hazrati, E. et al. (2006) Journal of immunology (Baltimore, Md. : 1950) 177, 8658-66. PMID: 17142766 4. Giesemann, T. et al. (2008) Gastroenterology 134, 2049-58. PMID: 18435932 5. Cardot-Martin, E. et al. (2015) Letters in applied microbiology 61, 158-64. PMID: 25963798 | ||||||||
| 注意事項 | For research use only. |
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