

| Каталожный номер | HB025014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Описание |
Anti-DES/Desmin Polyclonal Antibody (HB025014) is a rabbit polyclonal antibody detecting Desmin in ELISA, IHC, WB. Suitable for Human, Mouse, Dog, Rat, and Bovine.
Highlights
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| Реактивность видов | Human, Mouse, Rat | ||||||||
| Применения | ELISA, IHC, WB | ||||||||
| Хозяинский вид | Rabbit | ||||||||
| Клоональность | Polyclonal | ||||||||
| Изотип | IgG | ||||||||
| Иммуноген | E. coli - derived recombinant Human DES/Desmin (Met1-Leu470). | ||||||||
| Цель | Desmin, DES | ||||||||
| Очистка | Purified by antigen affinity column. | ||||||||
| Номер доступа | P17661 | ||||||||
| Форма | Liquid | ||||||||
| Буфер хранения | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии. |
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| Информация об использовании продукта |
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| Устойчивость и хранение | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| Фон | Desmin is a ~53 kDa protein. Muscle-specific type III intermediate filament essential for proper muscular structure and function. Plays a crucial role in maintaining the structure of sarcomeres, inter-connecting the Z-disks and forming the myofibrils, linking them not only to the sarcolemmal cytoskeleton, but also to the nucleus and mitochondria, thus providing strength for the muscle fiber during activity. In adult striated muscle they form a fibrous network connecting myofibrils to each other and to the plasma membrane from the periphery of the Z-line structures. May act as a sarcomeric microtubule-anchoring protein: specifically associates with detyrosinated tubulin-alpha chains, leading to buckled microtubules and mechanical resistance to contraction. Required for nuclear membrane integrity, via anchoring at the cell tip and nuclear envelope, resulting in maintenance of microtubule-derived intracellular mechanical forces. 1. Hnia, K. et al. (2015) Cell and tissue research 360, 591-608. PMID: 25358400 2. Brodehl, A. et al. (2013) Circulation. Cardiovascular genetics 6, 615-23. PMID: 24200904 3. Clemen, CS. et al. (2015) Acta neuropathologica 129, 297-315. PMID: 25394388 4. Brodehl, A. et al. (2016) Journal of molecular and cellular cardiology 91, 207-14. PMID: 26724190 | ||||||||
| Примечание | For research use only. |
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