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| カタログ番号 | HW773014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-DGKE Polyclonal Antibody (HW773014) is a rabbit polyclonal antibody detecting DGKE in ELISA, IHC, WB. Suitable for Human and Mouse.
Highlights
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| 種反応性 | Human, Mouse | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human DGKE (Leu243-Gly502). | ||||||||
| ターゲット | DGKE, Diglyceride kinase epsilon, DAG kinase epsilon, DGK-epsilon, Diacylglycerol kinase epsilon, DAGK5 | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | P52429 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Diacylglycerol kinase epsilon (DGKE) is a ~63 kDa protein. Membrane-bound diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids. Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes. Also plays an important role in the biosynthesis of complex lipids. Displays specificity for diacylglycerol substrates with an arachidonoyl acyl chain at the sn-2 position, with the highest activity toward 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol the main diacylglycerol intermediate within the phosphatidylinositol turnover cycle. Can also phosphorylate diacylglycerol substrates with a linoleoyl acyl chain at the sn-2 position but much less efficiently. 1. Epand, RM. et al. (2004) Biochemistry 43, 14778-83. PMID: 15544348 2. Lung, M. et al. (2009) The Journal of biological chemistry 284, 31062-73. PMID: 19744926 3. Shulga, YV. et al. (2011) Journal of molecular biology 409, 101-12. PMID: 21477596 4. Shulga, YV. et al. (2011) FEBS letters 585, 4025-8. PMID: 22108654 5. Sato, M. et al. (2013) Pharmacology 92, 99-107. PMID: 23949095 6. Tang, W. et al. (1996) The Journal of biological chemistry 271, 10237-41. PMID: 8626589 | ||||||||
| 注意事項 | For research use only. |
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