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| カタログ番号 | HF957014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-DHFR Polyclonal Antibody (HF957014) is a rabbit polyclonal antibody detecting DHFR in ELISA, IHC, WB. Suitable for Human, Mouse, Rat, Bovine, and Pig.
Highlights
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| 種反応性 | Human | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human DHFR (Met1-Asp187). | ||||||||
| ターゲット | Dihydrofolate reductase, DHFR | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | P00374 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Dihydrofolate reductase (DHFR) is a ~21 kDa protein. Catalyzes the reduction of 7,8-dihydrofolate (DHF) to 5,6,7,8-tetrahydrofolate in a NADPH-dependent manner. Key enzyme in folate metabolism. Contributes to the nuclear and mitochondrial de novo thymidylate biosynthesis pathway. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. Binds its own mRNA and that of DHFR2. 1. Klon, AE. et al. (2002) Journal of molecular biology 320, 677-93. PMID: 12096917 2. Cody, V. et al. (2004) Acta crystallographica. Section D, Biological crystallography 60, 646-55. PMID: 15039552 3. Reynolds, RC. et al. (2007) Journal of medicinal chemistry 50, 3283-9. PMID: 17569517 4. Cody, V. et al. (2009) Biochemistry 48, 1702-11. PMID: 19196009 5. Volpato, JP. et al. (2009) The Journal of biological chemistry 284, 20079-89. PMID: 19478082 6. McEntee, G. et al. (2011) Proceedings of the National Academy of Sciences of the United States of America 108, 15157-62. PMID: 21876184 7. Gangjee, A. et al. (1998) Journal of medicinal chemistry 41, 3426-34. PMID: 9719595 8. Anderson, DD. et al. (2011) Proceedings of the National Academy of Sciences of the United States of America 108, 15163-8. PMID: 21876188 9. Anderson, DD. et al. (2012) The Journal of biological chemistry 287, 7051-62. PMID: 22235121 | ||||||||
| 注意事項 | For research use only. |
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