Anti-DIO1 Polyclonal Antibody (HW476014)

Name: Anti-DIO1 Polyclonal Antibody
Brand: abinScience
SKU: HW476014
Price: 168 USD
Availability: InStock

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SDS

Aperçu

Numéro de catalogue

HW476014

Description

Anti-DIO1 Polyclonal Antibody (HW476014) is a rabbit polyclonal antibody detecting DIO1 in ELISA, IHC, WB. Suitable for Human, Mouse, and Rat.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

Reactivité des espèces

Human

Applications

ELISA, IHC, WB

Espèce hôte

Rabbit

Clonalité

Polyclonal

Isotype

IgG

Immunogène

E. coli - derived recombinant Human DIO1 (Gly89-Ser254).

Cible

Type I iodothyronine deiodinase, 1.21.99.4, 5DI, DIOI, Type 1 DI, Type-I 5'-deiodinase, DIO1, ITDI1, TXDI1

Purification

Purified by antigen affinity column.

Numéro d'accès

P49895

Forme

Liquid

Tampon de stockage

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.

Informations d'utilisation du produit

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stabilité et stockage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Contexte

Type I iodothyronine deiodinase (DIO1) is a ~28 kDa protein. Plays a crucial role in the metabolism of thyroid hormones (TH) and has specific roles in TH activation and inactivation by deiodination. Catalyzes the deiodination of L-thyroxine (T4) to 3,5,3'-triiodothyronine (T3), 3,3',5'-triiodothyronine (rT3) to 3,3'-diiodothyronine (3,3'-T2) and 3',5'-diiodothyronine (3',5'-T2) to 3'-monoiodothyronine (3'-T1) via outer-ring deiodination (ORD). Catalyzes the deiodination of T4 to 3,3',5'-triiodothyronine (rT3) via inner-ring deiodination (IRD). Catalyzes the deiodination of T3 to 3,3'-T2, 3,5-diiodothyronine (3,5-T2) to 3- monoiodothyronine (3-T1) and 3,3'-T2 to 3-T1 via IRD. Catalyzes the phenolic ring deiodinations of 3,3',5'-triiodothyronamine and 3',5'-diiodothyronamine.

1. Curcio-Morelli, C. et al. (2003) Endocrinology 144, 937-46. PMID: 12586771

2. França, MM. et al. (2021) Thyroid : official journal of the American Thyroid Association 31, 202-207. PMID: 32718224

3. Piehl, S. et al. (2008) Rapid communications in mass spectrometry : RCM 22, 3286-96. PMID: 18821722

4. Piehl, S. et al. (2008) Endocrinology 149, 3037-45. PMID: 18339710

Note

For research use only.

Images

Reférences

Fiche technique

Anti-DIO1 Polyclonal Antibody.pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

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