

| Número de catálogo | HV780014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Descripción |
Anti-DKK2 Polyclonal Antibody (HV780014) is a rabbit polyclonal antibody detecting DKK2 in ELISA, IHC, WB. Suitable for Human and Mouse.
Highlights
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| Reactividad de especies | Human, Mouse | ||||||||
| Aplicaciones | ELISA, IHC, WB | ||||||||
| Especie huésped | Rabbit | ||||||||
| Clonalidad | Polyclonal | ||||||||
| Isotipo | IgG | ||||||||
| Inmunógeno | E. coli - derived recombinant Human DKK2 (Lys34-Ile259). | ||||||||
| Objetivo | Dkk-2, hDkk-2, Dickkopf-related protein 2, DKK2, Dickkopf-2 | ||||||||
| Purificación | Purified by antigen affinity column. | ||||||||
| Número de acceso | Q9UBU2 | ||||||||
| Forma | Liquid | ||||||||
| Buffer de almacenamiento | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote. |
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| Información de uso del producto |
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| Estabilidad y almacenamiento | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| Fondo | Dickkopf-related protein 2 (DKK2) is a ~28 kDa protein. Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease. | ||||||||
| Nota | For research use only. |



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