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| カタログ番号 | HY347014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-DLD Polyclonal Antibody (HY347014) is a rabbit polyclonal antibody detecting DLD in ELISA, IHC, WB. Suitable for Human, Mouse, Dog, Rat, and Bovine.
Highlights
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| 種反応性 | Human, Mouse, Rat | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human DLD (Lys283-His487). | ||||||||
| ターゲット | Glycine cleavage system L protein, Dihydrolipoamide dehydrogenase, GCSL, DLD, PHE3, Dihydrolipoyl dehydrogenase, mitochondrial, LAD | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | P09622 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Dihydrolipoyl dehydrogenase, mitochondrial (DLD) is a ~54 kDa protein. Lipoamide dehydrogenase is a component of the glycine cleavage system as well as an E3 component of three alpha-ketoacid dehydrogenase complexes (pyruvate-, alpha-ketoglutarate-, and branched-chain amino acid-dehydrogenase complex). The 2-oxoglutarate dehydrogenase complex is mainly active in the mitochondrion. A fraction of the 2-oxoglutarate dehydrogenase complex also localizes in the nucleus and is required for lysine succinylation of histones: associates with KAT2A on chromatin and provides succinyl-CoA to histone succinyltransferase KAT2A. In monomeric form may have additional moonlighting function as serine protease. Involved in the hyperactivation of spermatazoa during capacitation and in the spermatazoal acrosome reaction. 1. Odièvre, MH. et al. (2005) Human mutation 25, 323-4. PMID: 15712224 2. Brautigam, CA. et al. (2006) Structure (London, England : 1993) 14, 611-21. PMID: 16442803 3. Cameron, JM. et al. (2006) American journal of medical genetics. Part A 140, 1542-52. PMID: 16770810 4. Babady, NE. et al. (2007) Proceedings of the National Academy of Sciences of the United States of America 104, 6158-63. PMID: 17404228 5. Patel, MS. et al. (2009) Journal of molecular catalysis. B, Enzymatic 61, 2-6. PMID: 20160912 6. Park, YH. et al. (2010) Biochemical and biophysical research communications 395, 416-9. PMID: 20385101 7. Wang, Y. et al. (2017) Nature 552, 273-277. PMID: 29211711 | ||||||||
| 注意事項 | For research use only. |
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