

| Numéro de catalogue | HB712014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Description |
Anti-DNASE1 Polyclonal Antibody (HB712014) is a rabbit polyclonal antibody detecting DNASE1 in ELISA, IHC, WB. Suitable for Human.
Highlights
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| Reactivité des espèces | Human | ||||||||
| Applications | ELISA, IHC, WB | ||||||||
| Espèce hôte | Rabbit | ||||||||
| Clonalité | Polyclonal | ||||||||
| Isotype | IgG | ||||||||
| Immunogène | E. coli - derived recombinant Human DNASE1 (Gly19-Ala259). | ||||||||
| Cible | DNL1, Deoxyribonuclease I, DNASE1, Dornase alfa, Deoxyribonuclease-1, DNase I, DRNI | ||||||||
| Purification | Purified by antigen affinity column. | ||||||||
| Numéro d'accès | P24855 | ||||||||
| Forme | Liquid | ||||||||
| Tampon de stockage | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot. |
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| Informations d'utilisation du produit |
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| Stabilité et stockage | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| Contexte | Deoxyribonuclease-1 (DNASE1) is a ~31 kDa protein. Serum endocuclease secreted into body fluids by a wide variety of exocrine and endocrine organs. Expressed by non-hematopoietic tissues and preferentially cleaves protein-free DNA. Among other functions, seems to be involved in cell death by apoptosis. Binds specifically to G-actin and blocks actin polymerization. Together with DNASE1L3, plays a key role in degrading neutrophil extracellular traps (NETs). 1. Oliveri, M. et al. (2001) European journal of immunology 31, 743-51. PMID: 11241278 2. Shak, S. et al. (1990) Proceedings of the National Academy of Sciences of the United States of America 87, 9188-92. PMID: 2251263 3. Yasuda, T. et al. (1990) Journal of biochemistry 108, 393-8. PMID: 2277032 | ||||||||
| Note | For research use only. |
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