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| カタログ番号 | HV233014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-DNMT3A Polyclonal Antibody (HV233014) is a rabbit polyclonal antibody detecting Dnmt3a in ELISA, IHC, WB. Suitable for Chicken, Human, Mouse, and Rat.
Highlights
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| 種反応性 | Human, Mouse, Rat | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human DNMT3A (Ala628-Val912). | ||||||||
| ターゲット | Dnmt3a, DNA MTase HsaIIIA, DNMT3A, M.HsaIIIA, DNA (cytosine-5)-methyltransferase 3A, DNA methyltransferase HsaIIIA | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | Q9Y6K1 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | DNA (cytosine-5)-methyltransferase 3A (DNMT3A) is a ~101 kDa protein. Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. It modifies DNA in a non-processive manner and also methylates non-CpG sites. May preferentially methylate DNA linker between 2 nucleosomal cores and is inhibited by histone H1. Plays a role in paternal and maternal imprinting. 1. Chen, T. et al. (2002) The Journal of biological chemistry 277, 38746-54. PMID: 12138111 2. Viré, E. et al. (2006) Nature 439, 871-4. PMID: 16357870 3. Heyn, P. et al. (2019) Nature genetics 51, 96-105. PMID: 30478443 | ||||||||
| 注意事項 | For research use only. |
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