

| Numéro de catalogue | HS757014 | ||||||||
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| Description |
Anti-DUSP6 Polyclonal Antibody (HS757014) is a rabbit polyclonal antibody detecting DUSP6 in ELISA, IHC, WB. Suitable for Bovine, Human, Mouse, and Rat.
Highlights
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| Reactivité des espèces | Human, Mouse, Rat | ||||||||
| Applications | ELISA, IHC, WB | ||||||||
| Espèce hôte | Rabbit | ||||||||
| Clonalité | Polyclonal | ||||||||
| Isotype | IgG | ||||||||
| Immunogène | E. coli - derived recombinant Human DUSP6 (Met1-Leu347). | ||||||||
| Cible | Mitogen-activated protein kinase phosphatase 3, MKP3, DUSP6, PYST1, MAP kinase phosphatase 3, Dual specificity protein phosphatase PYST1, Dual specificity protein phosphatase 6, MKP-3 | ||||||||
| Purification | Purified by antigen affinity column. | ||||||||
| Numéro d'accès | Q16828 | ||||||||
| Forme | Liquid | ||||||||
| Tampon de stockage | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot. |
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| Informations d'utilisation du produit |
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| Stabilité et stockage | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| Contexte | Dual specificity protein phosphatase 6 (DUSP6) is a ~42 kDa protein. Dual specificity protein phosphatase, which mediates dephosphorylation and inactivation of MAP kinases. Has a specificity for the ERK family. Plays an important role in alleviating chronic postoperative pain. Necessary for the normal dephosphorylation of the long-lasting phosphorylated forms of spinal MAPK1/3 and MAP kinase p38 induced by peripheral surgery, which drives the resolution of acute postoperative allodynia. Also important for dephosphorylation of MAPK1/3 in local wound tissue, which further contributes to resolution of acute pain. 1. Groom, LA. et al. (1996) The EMBO journal 15, 3621-32. PMID: 8670865 2. Mishra, A. et al. (2017) eLife 6. PMID: 29043977 | ||||||||
| Note | For research use only. |
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