

| Número de catálogo | VK074014 | ||||||||
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| Descripción |
Anti-EBV/HHV4 BMRF1 Polyclonal Antibody (VK074014) is a rabbit polyclonal antibody detecting DNA polymerase processivity factor BMRF1 in ELISA, IHC, WB.
Highlights
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| Reactividad de especies | Epstein-Barr virus (HHV-4) (Human herpesvirus 4) | ||||||||
| Aplicaciones | ELISA, IHC, WB | ||||||||
| Especie huésped | Rabbit | ||||||||
| Clonalidad | Polyclonal | ||||||||
| Isotipo | IgG | ||||||||
| Inmunógeno | E. coli - derived recombinant EBV/HHV4 BMRF1 (Met1-Ser314). | ||||||||
| Objetivo | DNA polymerase processivity factor BMRF1, Early Antigen Diffused, EA-D, Polymerase accessory subunit | ||||||||
| Nivel de endotoxinas | Please contact with the lab for this information. | ||||||||
| Purificación | Purified by antigen affinity column. | ||||||||
| Número de acceso | P03191 | ||||||||
| Forma | Liquid | ||||||||
| Buffer de almacenamiento | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote. |
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| Información de uso del producto |
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| Estabilidad y almacenamiento | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| Fondo | DNA polymerase processivity factor BMRF1 is a ~43 kDa protein. Acts as a DNA polymerase processivity factor; a transcriptional activator for several EBV promoters and inhibits the host DNA damage response (DDR) to double-stranded DNA breaks. Plays an essential role in the viral lytic DNA replication by acting as a polymerase accessory subunit. Stimulates the viral DNA polymerase activity and appears to function with it as a holoenzyme. Increases the processivity of the viral polymerase, probably by acting as a sliding clamp that prevents dissociation of the polymerase from the active template. In addition, BMRF1 transcriptionally activates the oriLyt early BHLF1 promoter. 1. Neuhierl, B. et al. (2006) Journal of virology 80, 5078-81. PMID: 16641300 2. Murayama, K. et al. (2009) The Journal of biological chemistry 284, 35896-905. PMID: 19801550 3. Salamun, SG. et al. (2019) Journal of virology 93. PMID: 31462557 4. Zhang, Q. et al. (1996) Journal of virology 70, 5131-42. PMID: 8764021 5. Zhang, Q. et al. (1997) Virology 230, 22-34. PMID: 9126259 | ||||||||
| Nota | For research use only |
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