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| カタログ番号 | VK074014 | ||||||||
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| 説明 |
Anti-EBV/HHV4 BMRF1 Polyclonal Antibody (VK074014) is a rabbit polyclonal antibody detecting DNA polymerase processivity factor BMRF1 in ELISA, IHC, WB.
Highlights
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| 種反応性 | Epstein-Barr virus (HHV-4) (Human herpesvirus 4) | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant EBV/HHV4 BMRF1 (Met1-Ser314). | ||||||||
| ターゲット | DNA polymerase processivity factor BMRF1, Early Antigen Diffused, EA-D, Polymerase accessory subunit | ||||||||
| エンドトキシンレベル | Please contact with the lab for this information. | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | P03191 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | DNA polymerase processivity factor BMRF1 is a ~43 kDa protein. Acts as a DNA polymerase processivity factor; a transcriptional activator for several EBV promoters and inhibits the host DNA damage response (DDR) to double-stranded DNA breaks. Plays an essential role in the viral lytic DNA replication by acting as a polymerase accessory subunit. Stimulates the viral DNA polymerase activity and appears to function with it as a holoenzyme. Increases the processivity of the viral polymerase, probably by acting as a sliding clamp that prevents dissociation of the polymerase from the active template. In addition, BMRF1 transcriptionally activates the oriLyt early BHLF1 promoter. 1. Neuhierl, B. et al. (2006) Journal of virology 80, 5078-81. PMID: 16641300 2. Murayama, K. et al. (2009) The Journal of biological chemistry 284, 35896-905. PMID: 19801550 3. Salamun, SG. et al. (2019) Journal of virology 93. PMID: 31462557 4. Zhang, Q. et al. (1996) Journal of virology 70, 5131-42. PMID: 8764021 5. Zhang, Q. et al. (1997) Virology 230, 22-34. PMID: 9126259 | ||||||||
| 注意事項 | For research use only |
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