Anti-EDN1/Endothelin1 Polyclonal Antibody (HY182014)

Name: Anti-EDN1/Endothelin1 Polyclonal Antibody
Brand: abinScience
SKU: HY182014
Price: 168 USD
Availability: InStock

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Datasheet
SDS

Vista general

Número de catálogo

HY182014

Descripción

Anti-EDN1/Endothelin1 Polyclonal Antibody (HY182014) is a rabbit polyclonal antibody detecting Endothelin1 in ELISA, IHC, WB. Suitable for Human and Macaca fascicularis.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

Reactividad de especies

Human

Aplicaciones

ELISA, IHC, WB

Especie huésped

Rabbit

Clonalidad

Polyclonal

Isotipo

IgG

Inmunógeno

E. coli - derived recombinant Human EDN1 (Ala18-Trp212).

Objetivo

Endothelin-1, EDN1, PPET1, ET-1, Preproendothelin-1, Endothelin1

Purificación

Purified by antigen affinity column.

Número de acceso

P05305

Forma

Liquid

Buffer de almacenamiento

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.

Información de uso del producto

Aplicación	Dilución
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Estabilidad y almacenamiento

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Fondo

Endothelin-1 (EDN1) is a ~24 kDa protein. Endothelins are endothelium-derived vasoconstrictor peptides. Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells. Also binds the DEAR/FBXW7-AS1 receptor. Promotes mesenteric arterial wall remodeling via activation of ROCK signaling and subsequent colocalization of NFATC3 with F-actin filaments. NFATC3 then translocates to the nucleus where it subsequently promotes the transcription of the smooth muscle hypertrophy and differentiation marker ACTA2.

1. Rufanova, VA. et al. (2009) Journal of cellular physiology 219, 45-56. PMID: 19086031

2. Glorioso, N. et al. (2007) Circulation research 100, 1522-9. PMID: 17446437

Nota

For research use only.

Imágenes

Referencias

Datasheet

Anti-EDN1/Endothelin1 Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Proteínas Recombinantes

Anticuerpos

Kits de Ensayo