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| カタログ番号 | HF514014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-EFEMP2 Polyclonal Antibody (HF514014) is a rabbit polyclonal antibody detecting EFEMP2 in ELISA, IHC, WB. Suitable for Human, Mouse, and Cricetulus griseus.
Highlights
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| 種反応性 | Human, Mouse | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human EFEMP2 (Ser26-Phe443). | ||||||||
| ターゲット | EGF-containing fibulin-like extracellular matrix protein 2, Protein UPH1, Fibulin-4, FBLN4, EFEMP2, FIBL-4 | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | O95967 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | EGF-containing fibulin-like extracellular matrix protein 2 (EFEMP2) is a ~49 kDa protein. Plays a crucial role in elastic fiber formation in tissue, and in the formation of ultrastructural connections between elastic laminae and smooth muscle cells in the aorta, therefore participates in terminal differentiation and maturation of smooth muscle cell (SMC) and in the mechanical properties and wall integrity maintenance of the aorta. In addition, is involved in the control of collagen fibril assembly in tissue throught proteolytic activation of LOX leading to cross- linking of collagen and elastin. Also promotes ELN coacervation and participates in the deposition of ELN coacervates on to microfibrils but also regulates ELN cross- linking through LOX interaction. Moreover adheres to the cells through heparin binding in a calcium-dependent manner and regulates vascularlar smooth muscle cells proliferation through angiotensin signaling. 1. Sasaki, T. et al. (2016) Matrix biology : journal of the International Society for Matrix Biology 56, 132-149. PMID: 27339457 2. Cirulis, JT. et al. (2008) Biochemistry 47, 12601-13. PMID: 18973305 3. Choudhury, R. et al. (2009) The Journal of biological chemistry 284, 24553-67. PMID: 19570982 4. Djokic, J. et al. (2013) The Journal of biological chemistry 288, 22821-35. PMID: 23782690 | ||||||||
| 注意事項 | For research use only. |
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