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Anti-ELAVL4/HuD/Hu-antigen D Polyclonal Antibody (HB290014)

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Vista general
Número de catálogoHB290014
Descripción
Anti-ELAVL4/HuD/Hu-antigen D Polyclonal Antibody (HB290014) is a rabbit polyclonal antibody detecting Hu-antigen D in ELISA, IHC, WB. Suitable for Human, Mouse, Rat, Danio rerio, and Pongo abelii.
Highlights
  • ●Affinity Purified — Minimal background and high purity for reliable results.
  • ●Multi-Application — Validated across multiple applications.
  • ●Multi-Species — Cross-reactive for translational research.
Reactividad de especiesHuman, Mouse, Rat
AplicacionesELISA, IHC, WB
Especie huéspedRabbit
ClonalidadPolyclonal
IsotipoIgG
Inmunógeno E. coli - derived recombinant Human ELAVL4/HuD/Hu-antigen D (Val2-Ser380).
Objetivo Paraneoplastic encephalomyelitis antigen HuD, HUD, Hu-antigen D, ELAVL4, PNEM, HuD, ELAV-like protein 4
Purificación Purified by antigen affinity column.
Número de acceso P26378
Forma Liquid
Buffer de almacenamiento 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.

Información de uso del producto
Aplicación Dilución
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Estabilidad y almacenamiento Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Fondo

ELAV-like protein 4 (ELAVL4/HuD) is a ~42 kDa protein. RNA-binding protein that is involved in the post-transcriptional regulation of mRNAs. Plays a role in the regulation of mRNA stability, alternative splicing and translation. Binds to AU-rich element (ARE) sequences in the 3' untranslated region (UTR) of target mRNAs, including GAP43, VEGF, FOS, CDKN1A and ACHE mRNA. Many of the target mRNAs are coding for RNA-binding proteins, transcription factors and proteins involved in RNA processing and/or neuronal development and function. By binding to the mRNA 3'UTR, decreases mRNA deadenylation and thereby contributes to the stabilization of mRNA molecules and their protection from decay.

1. King, PH. (2000) Nucleic acids research 28, E20. PMID: 10710437
2. Beckel-Mitchener, AC. et al. (2002) The Journal of biological chemistry 277, 27996-8002. PMID: 12034726
3. Deschenes-Furry, J. et al. (2003) The Journal of biological chemistry 278, 5710-7. PMID: 12468554
4. Zhu, H. et al. (2006) Molecular biology of the cell 17, 5105-14. PMID: 17035636
5. Deschênes-Furry, J. et al. (2007) The Journal of neuroscience : the official journal of the Society for Neuroscience 27, 665-75. PMID: 17234598
6. Liu, J. et al. (1995) Neurology 45, 544-50. PMID: 7898713
Nota For research use only.
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Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)
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Formula
C₁ × V₁ = C₂ × V₂
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Stock Solution
C₁ (Stock Conc.)
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V₁ (Stock Vol.)
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Working Solution
C₂ (Working Conc.)
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V₂ (Working Vol.)
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