Anti-ELAVL4/HuD/Hu-antigen D Polyclonal Antibody (HB290014)

Name: Anti-ELAVL4/HuD/Hu-antigen D Polyclonal Antibody
Brand: abinScience
SKU: HB290014
Price: 168 USD
Availability: InStock

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SDS

Aperçu

Numéro de catalogue

HB290014

Description

Anti-ELAVL4/HuD/Hu-antigen D Polyclonal Antibody (HB290014) is a rabbit polyclonal antibody detecting Hu-antigen D in ELISA, IHC, WB. Suitable for Human, Mouse, Rat, Danio rerio, and Pongo abelii.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

Reactivité des espèces

Human, Mouse, Rat

Applications

ELISA, IHC, WB

Espèce hôte

Rabbit

Clonalité

Polyclonal

Isotype

IgG

Immunogène

E. coli - derived recombinant Human ELAVL4/HuD/Hu-antigen D (Val2-Ser380).

Cible

Paraneoplastic encephalomyelitis antigen HuD, HUD, Hu-antigen D, ELAVL4, PNEM, HuD, ELAV-like protein 4

Purification

Purified by antigen affinity column.

Numéro d'accès

P26378

Forme

Liquid

Tampon de stockage

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.

Informations d'utilisation du produit

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stabilité et stockage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Contexte

ELAV-like protein 4 (ELAVL4/HuD) is a ~42 kDa protein. RNA-binding protein that is involved in the post-transcriptional regulation of mRNAs. Plays a role in the regulation of mRNA stability, alternative splicing and translation. Binds to AU-rich element (ARE) sequences in the 3' untranslated region (UTR) of target mRNAs, including GAP43, VEGF, FOS, CDKN1A and ACHE mRNA. Many of the target mRNAs are coding for RNA-binding proteins, transcription factors and proteins involved in RNA processing and/or neuronal development and function. By binding to the mRNA 3'UTR, decreases mRNA deadenylation and thereby contributes to the stabilization of mRNA molecules and their protection from decay.

1. King, PH. (2000) Nucleic acids research 28, E20. PMID: 10710437

2. Beckel-Mitchener, AC. et al. (2002) The Journal of biological chemistry 277, 27996-8002. PMID: 12034726

3. Deschenes-Furry, J. et al. (2003) The Journal of biological chemistry 278, 5710-7. PMID: 12468554

4. Zhu, H. et al. (2006) Molecular biology of the cell 17, 5105-14. PMID: 17035636

5. Deschênes-Furry, J. et al. (2007) The Journal of neuroscience : the official journal of the Society for Neuroscience 27, 665-75. PMID: 17234598

6. Liu, J. et al. (1995) Neurology 45, 544-50. PMID: 7898713

Note

For research use only.

Images

Reférences

Fiche technique

Anti-ELAVL4/HuD/Hu-antigen D Polyclonal Antibody.pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

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