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| カタログ番号 | HB290014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-ELAVL4/HuD/Hu-antigen D Polyclonal Antibody (HB290014) is a rabbit polyclonal antibody detecting Hu-antigen D in ELISA, IHC, WB. Suitable for Human, Mouse, Rat, Danio rerio, and Pongo abelii.
Highlights
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| 種反応性 | Human, Mouse, Rat | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human ELAVL4/HuD/Hu-antigen D (Val2-Ser380). | ||||||||
| ターゲット | Paraneoplastic encephalomyelitis antigen HuD, HUD, Hu-antigen D, ELAVL4, PNEM, HuD, ELAV-like protein 4 | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | P26378 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | ELAV-like protein 4 (ELAVL4/HuD) is a ~42 kDa protein. RNA-binding protein that is involved in the post-transcriptional regulation of mRNAs. Plays a role in the regulation of mRNA stability, alternative splicing and translation. Binds to AU-rich element (ARE) sequences in the 3' untranslated region (UTR) of target mRNAs, including GAP43, VEGF, FOS, CDKN1A and ACHE mRNA. Many of the target mRNAs are coding for RNA-binding proteins, transcription factors and proteins involved in RNA processing and/or neuronal development and function. By binding to the mRNA 3'UTR, decreases mRNA deadenylation and thereby contributes to the stabilization of mRNA molecules and their protection from decay. 1. King, PH. (2000) Nucleic acids research 28, E20. PMID: 10710437 2. Beckel-Mitchener, AC. et al. (2002) The Journal of biological chemistry 277, 27996-8002. PMID: 12034726 3. Deschenes-Furry, J. et al. (2003) The Journal of biological chemistry 278, 5710-7. PMID: 12468554 4. Zhu, H. et al. (2006) Molecular biology of the cell 17, 5105-14. PMID: 17035636 5. Deschênes-Furry, J. et al. (2007) The Journal of neuroscience : the official journal of the Society for Neuroscience 27, 665-75. PMID: 17234598 6. Liu, J. et al. (1995) Neurology 45, 544-50. PMID: 7898713 | ||||||||
| 注意事項 | For research use only. |
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